Jiejun Wu
Janssen Pharmaceutica
97 Papers
536 Citations
Jiejun Wu is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Receptor & Branching fraction. The author has an hindex of 30, co-authored 96 publications. Previous affiliations of Jiejun Wu include Syracuse University & Johnson & Johnson Pharmaceutical Research and Development.
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Papers
Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81
Changlu Liu,Jiejun Wu,Jessica Zhu,Chester Kuei,Jingxue Yu,Jonathan Shelton,Steven W. Sutton,Xiaorong Li,Su Jin Yun,Taraneh Mirzadegan,Curt Mazur,Fredrik Kamme,Timothy W. Lovenberg +12 more
TL;DR: The results indicate that lactate suppresses lipolysis in adipose tissue through a direct activation of GPR81 and may be an attractive target for the treatment of dyslipidemia and other metabolic disorders.
515
Oxysterols direct B-cell migration through EBI2
Changlu Liu,Xia V. Yang,Jiejun Wu,Chester Kuei,Neelakandha S. Mani,Li Zhang,Jingxue Yu,Steven W. Sutton,Ning Qin,Ning Qin,Homayon Banie,Lars Karlsson,Lars Karlsson,Siquan Sun,Timothy W. Lovenberg +14 more
TL;DR: The results show an unexpected causal link between EBI2, an orphan G-protein-coupled receptor controlling B-cell migration, and the known immunological effects of certain oxysterols, thus uncovering a previously unknown role for this class of molecules.
368
Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation
Pejman Soroosh,Jiejun Wu,Xiaohua Xue,Jiao Song,Steven W. Sutton,Marciano Sablad,Jingxue Yu,Marina I. Nelen,Xuejun Liu,Glenda Castro,Rosa Luna,Shelby Crawford,Homayon Banie,Rose A. Dandridge,Xiaohu Deng,Anton Bittner,Chester Kuei,Mandana Tootoonchi,Natasha Rozenkrants,Krystal Herman,Jingjin Gao,Xia V. Yang,Kacey L. Sachen,Karen Ngo,Wai-Ping Fung-Leung,Steven Nguyen,Aimee De Leon-Tabaldo,Jonathan M. Blevitt,Yan Zhang,Maxwell D. Cummings,Tadimeti S. Rao,Neelakandha S. Mani,Changlu Liu,Murray McKinnon,Marcos E. Milla,Anne M. Fourie,Siquan Sun +36 more
TL;DR: Evidence is presented that 7β, 27-dihydroxycholesterol and 7α,27-OHC are RORγt agonist ligands and may serve as potential endogenous R ORγt ligands in promoting the differentiation of mouse and human CD4+ Th17 cells, and it is shown that Th17, but not Th1 cells, preferentially produce these two oxysterols.
239
INSL5 is a high affinity specific agonist for GPCR142 (GPR100).
Changlu Liu,Chester Kuei,Steven W. Sutton,Jingcai Chen,Pascal Bonaventure,Jiejun Wu,Diane Nepomuceno,Fredrik Kamme,Da-Thao Tran,Jessica Zhu,Tracey N. Wilkinson,Ross A. D. Bathgate,Elo Eriste,Rannar Sillard,Timothy W. Lovenberg +14 more
TL;DR: The high affinity interaction between InSL5 and GPCR142 coupled with their co-evolution and partially overlapping tissue expression patterns strongly suggest that INSL5 is an endogenous ligand for GPCr142.
209
Search for Charmless [Formula presented] Decays
R. Godang,I. P.J. Shipsey,G. Bonvicini,D. Cinabro,M. Dubrovin,S. McGee,G. J. Zhou,Adolf Bornheim,E. Lipeles,S. P. Pappas,M. Schmidtler,A. Shapiro,W. M. Sun,A. J. Weinstein,D. E. Jaffe,G. Masek,H. P. Paar,D. M. Asner,A. Eppich,T. S. Hill,R. J. Morrison,R. A. Briere,G. P. Chen,Thomas Ferguson,Hans J. Vogel,A. Gritsan,J. P. Alexander,R. Baker,C. Bebek,B. E. Berger,Karl Berkelman,F. Blanc,V. Boisvert,D. G. Cassel,P. S. Drell,J. E. Duboscq,K. M. Ecklund,R. Ehrlich,A. D. Foland,P. Gaidarev,L. K. Gibbons,B. Gittelman,S. W. Gray,D. L. Hartill,B. K. Heltsley,P. I. Hopman,L. Hsu,C. D. Jones,J. Kandaswamy,D. L. Kreinick,M. Lohner,A. Magerkurth,T. O. Meyer,N. B. Mistry,E. Nordberg,M.A. Palmer,Juliet Ritchie Patterson,D. Peterson,D. Riley,A. Romano,J. G. Thayer,D. Urner,B. Valant-Spaight,G. Viehhauser,Andreas Warburton,Paul Avery,C.Y. Prescott,A. I. Rubiera,H. Stoeck,John Yelton,G. W. Brandenburg,A. Ershov,D. Y.J. Kim,Richard Wilson,T. Bergfeld,B. I. Eisenstein,J. Ernst,G. E. Gladding,George D Gollin,R. M. Hans,E. Johnson,I. Karliner,M. A. Marsh,C. Plager,C. Sedlack,Mats A Selen,J. J. Thaler,J. Williams,K. W. Edwards,R. Janicek,P. M. Patel,A. J. Sadoff,R. Ammar,Alice Bean,D. Z. Besson,X. Zhao,S. Anderson,V. V. Frolov,Yuichi Kubota,S. J. Lee,R. Mahapatra,J. J. O'Neill,R. Poling,T. Riehle,A. Smith,C. J. Stepaniak,J. Urheim,S. Ahmed,M. S. Alam,S. B. Athar,L. Jian,L. Ling,M. Saleem,S.C. Timm,F. R. Wappler,A. Anastassov,E. Eckhart,K. K. Gan,C. Gwon,T. Hart,K. Honscheid,D. Hufnagel,H. Kagan,R. D. Kass,T. K. Pedlar,H. Schwarthoff,J. B. Thayer,E. von Toerne,M. M. Zoeller,S. J. Richichi,Horst Severini,P. Skubic,A. Undrus,V. Savinov,Shuai Chen,J. Fast,J. W. Hinson,Jason Sang Hun Lee,D. H. Miller,V. Pavlunin,E. I. Shibata,Daniel P Cronin-Hennessy,A. L. Lyon,E. H. Thorndike,T. E. Coan,V. Fadeyev,Y. S. Gao,Yurii Maravin,I. Narsky,Ryszard Stroynowski,Jianqiao Ye,T. Wlodek,Marina Artuso,R. Ayad,C. Boulahouache,K. Bukin,E. Dambasuren,G. Majumder,G. C. Moneti,R. Mountain,S. Schuh,Tomasz Skwarnicki,Sheldon Stone,Jing Wang,A. Wolf,Jiejun Wu,Sacha E Kopp,M. Kostin,A. H. Mahmood,S. E. Csorna,I. Danko,K. W. McLean,Z. Xu +172 more
TL;DR: Two-body charmless decays of the B meson into the final states using only decay modes with charged daughter particles are studied using 9.7x10(6) BB pairs collected with the CLEO detector.