https://doi.org/10.1016/j.bioactmat.2022.05.009

Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation

The search for higher-quality nanomaterials for medicinal applications continues. There are similarities between electrospun fibers and natural tissues. This property has enabled electrospun fibers to make significant progress in medical applications. However, electrospun fibers are limited to tissue scaffolding applications. When nanoparticles and nanofibers are combined, the composite material can perform more functions, such as photothermal, magnetic response, biosensing, antibacterial, drug delivery and biosensing. To prepare nanofiber and nanoparticle hybrids (NNHs), there are two primary ways. The electrospinning technology was used to produce NNHs in a single step. An alternate way is to use a self-assembly technique to create nanoparticles in fibers. This paper describes the creation of NNHs from routinely used biocompatible polymer composites. Single-step procedures and self-assembly methodologies are used to discuss the preparation of NNHs. It combines recent research discoveries to focus on the application of NNHs in drug release, antibacterial, and tissue engineering in the last two years.

/pdf/polymer-based-nanofiber-nanoparticle-hybrids-and-their-7s7slxp7.pdf

Polymer-Based Nanofiber–Nanoparticle Hybrids and Their Medical Applications

Abstract Versatile strategies have been developed to construct electrospun fiber-based drug delivery systems for tissue regeneration and cancer therapy. We first introduce the construction of electrospun fiber scaffolds and their various structures, as well as various commonly used types of drugs. Then, we discuss some representative strategies for controlling drug delivery by electrospun fibers, with specific emphasis on the design of endogenous and external stimuli-responsive drug delivery systems. Afterwards, we summarize the recent progress on controlling drug delivery with electrospun fiber scaffolds for tissue engineering, including soft tissue engineering (such as skin, nerve, and cardiac repair) and hard tissue engineering (such as bone, cartilage, and musculoskeletal systems), as well as for cancer therapy. Furthermore, we provide future development directions and challenges facing the use of electrospun fibers for controlled drug delivery, aiming to provide insights and perspectives for the development of smart drug delivery platforms and improve clinical therapeutic effects in tissue regeneration and cancer therapy. Graphical abstract 

https://link.springer.com/content/pdf/10.1007/s42765-022-00198-9.pdf

Electrospun Fibers Control Drug Delivery for Tissue Regeneration and Cancer Therapy

Nanotechnology is one of the most promising technologies available today, holding tremendous potential for biomedical and healthcare applications. In this field, there is an increasing interest in the use of polymeric micro/nanofibers for the construction of biomedical structures. Due to its potential applications in various fields like pharmaceutics and biomedicine, the electrospinning process has gained considerable attention for producing nano-sized fibers. Electrospun nanofiber membranes have been used in drug delivery, controlled drug release, regenerative medicine, tissue engineering, biosensing, stent coating, implants, cosmetics, facial masks, and theranostics. Various natural and synthetic polymers have been successfully electrospun into ultrafine fibers. Although biopolymers demonstrate exciting properties such as good biocompatibility, non-toxicity, and biodegradability, they possess poor mechanical properties. Hybrid nanofibers from bio and synthetic nanofibers combine the characteristics of biopolymers with those of synthetic polymers, such as high mechanical strength and stability. In addition, a variety of functional agents, such as nanoparticles and biomolecules, can be incorporated into nanofibers to create multifunctional hybrid nanofibers. Due to the remarkable properties of hybrid nanofibers, the latest research on the unique properties of hybrid nanofibers is highlighted in this study. Moreover, various established hybrid nanofiber fabrication techniques, especially the electrospinning-based methods, as well as emerging strategies for the characterization of hybrid nanofibers, are summarized. Finally, the development and application of electrospun hybrid nanofibers in biomedical applications are discussed.

/pdf/electrospun-hybrid-nanofibers-fabrication-characterization-5q9ha5rm.pdf

Electrospun hybrid nanofibers: Fabrication, characterization, and biomedical applications

Rare earth elements (REEs) have gained spotlights with particular features to promote bone regeneration. Therefore, the introduction of appropriate REEs into bone tissue engineering (BTE) scaffolds is nowadays a promising strategy in order to achieve optimized bone repair performances. In this review, direct uses of REE compound nanoadditives in BTE scaffolds are first of all reviewed to illustrate the fundamental effects of REE towards bone regeneration. Then the Re-containing biodegradable porous alloys and Re-doped bioceramic-based scaffolds are discussed, respectively. REEs play functional roles in those materials with physical, chemical and biological improvements. Moreover, REEs-related biological effects including osteogenic, angiogenic and anti-bacterial properties that facilitate bone regeneration are also reviewed. This study is aiming to invoke diverse and comprehensive studies to investigate and improve the utilization of REEs in bone tissue engineering. 

The role of rare earth elements in bone tissue engineering scaffolds - A review

Cerium oxide nanoparticles loaded nanofibrous membranes promote bone regeneration for periodontal tissue engineering.

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Cerium oxide nanoparticles loaded nanofibrous membranes promote bone regeneration for periodontal tissue engineering.