Jie Yang
Sun Yat-sen University
5 Papers
28 Citations
Jie Yang is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Peripheral nerve injury & Nerve injury. The author has an hindex of 4, co-authored 4 publications.
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Papers
Bulleyaconitine A attenuates hyperexcitability of dorsal root ganglion neurons induced by spared nerve injury: The role of preferably blocking Nav1.7 and Nav1.3 channels
TL;DR: It is found that Bulleyaconitine A at 5 nM increased the threshold of action potentials and reduced the firing rate of dorsal root ganglion neurons in spared nerve injury rats but not in sham rats, and facilitated the inactivation of Nav channels in each subtype.
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Bulleyaconitine A preferably reduces tetrodotoxin-sensitive sodium current in uninjured dorsal root ganglion neurons of neuropathic rats probably via inhibition of protein kinase C.
Man-Xiu Xie,Rui-Ping Pang,Jie Yang,Kai-Feng Shen,Jing Xu,Xiongxiong Zhong,Shao-Kun Wang,Xiao-Long Zhang,Yan-Qing Liu,Xian-Guo Liu +9 more
TL;DR: It was found that BLA preferably inhibited Na+ currents in uninjured DRG neurons in neuropathic rats, and preferable blockage of TTX-S Na+ channels in unin injured DRg neurons may contribute to BLA's antineuropathic pain effect.
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Downregulation of ClC-3 in dorsal root ganglia neurons contributes to mechanical hypersensitivity following peripheral nerve injury
Rui-Ping Pang,Man-Xiu Xie,Jie Yang,Kai-Feng Shen,Xi Chen,Ying-Xue Su,Chao Yang,Jing Tao,Si-Jia Liang,Jia-Guo Zhou,He-Quan Zhu,Xu-Hong Wei,Yong-Yong Li,Zhihai Qin,Xian-Guo Liu +14 more
TL;DR: It is found that ClC-3 is expressed at high levels in dorsal root ganglia (DRG), and co-immunofluorescent data showed that it is mainly distributed in A- and C-type nociceptive neurons.
14
N-Methyl D-aspartate receptor subtype 2B/Ca2+/calmodulin-dependent protein kinase II signaling in the lateral habenula regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia
TL;DR: Findings suggest that activation of NMDA/CaMKII signaling in the LHb contributes to the occurrence and development of TN and related anxiety-like behaviors, and suppressing the activity of CaMKII+ neurons in the bilateral LHb by targeting NMDA/, may represent a novel strategy for treating pain and anxiety associated with TN.
Upregulation of N-type calcium channels in the soma of uninjured dorsal root ganglion neurons contributes to neuropathic pain by increasing neuronal excitability following peripheral nerve injury.
Jie Yang,Man-Xiu Xie,Li Hu,Xiao-Fang Wang,Jie-Zhen Mai,Yong-Yong Li,Ning Wu,Cheng Zhang,Jin Li,Rui-Ping Pang,Xian-Guo Liu +10 more
TL;DR: Data indicate that the upregulation of Cav2.2 in uninjured DRG neurons via IL-1β over-production contributes to neuropathic pain by increasing neuronal excitability following peripheral nerve injury.