Jie Chen
Cornell University
38 Papers
94 Citations
Jie Chen is an academic researcher from Cornell University. The author has contributed to research in topics: Kidney & Fibrosis. The author has an hindex of 19, co-authored 38 publications. Previous affiliations of Jie Chen include Genzyme & NewYork–Presbyterian Hospital.
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Papers
A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction
TL;DR: This study provides a proof of concept that peptides which protect mitochondria in vitro can provide protection from renal damage in a UUO model, with both the 1 and 3 mg/kg doses showing efficacy.
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Dietary arginine supplementation attenuates renal damage after relief of unilateral ureteral obstruction in rats1
Keiichi Ito,Jie Chen,Surya V. Seshan,Jonathan J. Khodadadian,Rachel Gallagher,Maher E.L. Chaar,Edarracott Vaughan,Dix P. Poppas,Diane Felsen +8 more
TL;DR: Dietary ARG supplementation during UUO relief did not improve ERPF or GFR, however, renal damage, including fibrosis, apoptosis, and macrophage infiltration was significantly improved by ARG treatment, suggesting that increasing NO availability could be beneficial in the setting of U UO relief.
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CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking.
Szu Yi Chou,Szu Yi Chou,Kuo-Shun Hsu,Wataru Otsu,Ya Chu Hsu,Yun Cin Luo,Celine Yeh,Syed S. Shehab,Jie Chen,Vincent Shieh,Guo An He,Michael B. Marean,Diane Felsen,Aihao Ding,Dix P. Poppas,Jen-Zen Chuang,Ching-Hwa Sung +16 more
TL;DR: It is shown that CLIC4-null mouse embryos exhibit impaired renal tubulogenesis, and that retromer- and branched actin-mediated trafficking on early endosome regulates apical delivery during early luminogenesis.
Nerve Sparing Ventral Clitoroplasty Preserves Dorsal Nerves in Congenital Adrenal Hyperplasia
TL;DR: Scarcity of large dorsal nerves in histological specimens excised using nerve sparing ventral clitoroplasty likely reflects their preservation within the congenital adrenal hyperplasia patients, vital to future somatosensory and motor function of the clitoris.
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Inducible Nitric Oxide Synthase Promotes Pathophysiological Consequences of Experimental Bladder Outlet Obstruction
Diane Felsen,Kambiz Dardashti,Michael Ostad,Matthew L. Lemer,Steven S. Gross,Jie Chen,E.D. Vaughan,Dix P. Poppas +7 more
TL;DR: Pharmacological or genetic decreases in iNOS resulted in amelioration of functional and fibrotic changes in the bladder after partial bladder outlets obstruction, suggesting that NO contributes to the pathophysiology of bladder outlet obstruction.
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