13 Papers
222 Citations
Jiayi Yu is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: T cell & Cellular differentiation. The author has an hindex of 10, co-authored 11 publications.
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Papers
The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity.
Mikyoung Chang,Wei Jin,Wei Jin,Jae Hoon Chang,Yichuan Xiao,George C. Brittain,Jiayi Yu,Xiaofei Zhou,Yi Hong Wang,Xuhong Cheng,Pingwei Li,Brian Rabinovich,Patrick Hwu,Shao Cong Sun +13 more
TL;DR: It is shown that genetic deficiency in the ubiquitin ligase Peli1 caused hyperactivation of T cells and rendered T cells refractory to suppression by regulatory T Cells and transforming growth factor-β (TGF-β).
The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling
Jin Jin,Yichuan Xiao,Jae Hoon Chang,Jiayi Yu,Hongbo Hu,Robyn Starr,George C. Brittain,Mikyoung Chang,Xuhong Cheng,Shao Cong Sun +9 more
TL;DR: In this paper, the authors identify the kinase TBK1 as a pivotal negative regulator of class switching to the immunoglobulin A (IgA) isotype.
Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation
Jiayi Yu,Xiaofei Zhou,Mikyoung Chang,Mako Nakaya,Jae Hoon Chang,Yichuan Xiao,J. William Lindsey,Stephanie Dorta-Estremera,Wei Cao,Anna Zal,Tomasz Zal,Shao Cong Sun +11 more
TL;DR: It is shown that T-cell-specific ablation of the kinase TBK1 promotes T- cell activation but causes retention of effector T cells in the draining lymph node in a neuroinflammatory autoimmunity model, experimental autoimmune encephalomyelitis (EAE).
Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK.
TL;DR: It is shown that NF-kappaB-inducing kinase (NIK), which is known to regulate B-cell maturation and lymphoid organogenesis, is important for the induction of Th17 cells, and that NIK mediates synergistic activation of STAT3 by T-cell receptor and IL-6 receptor signals.
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The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming.
Xiaofei Zhou,Jiayi Yu,Xuhong Cheng,Baoyu Zhao,Ganiraju C. Manyam,Li Zhang,Li Zhang,Kimberly S. Schluns,Kimberly S. Schluns,Pingwei Li,Jing Wang,Jing Wang,Shao Cong Sun,Shao Cong Sun +13 more
TL;DR: It is shown that IL-15 also mediates homeostatic priming of CD8+ T cells for antigen-stimulated activation, which is controlled by a deubiquitinase, Otub1, which controls the maturation and activation of NK cells.