Jiaping Gao
Novartis
13 Papers
95 Citations
Jiaping Gao is an academic researcher from Novartis. The author has contributed to research in topics: Pyruvate dehydrogenase kinase & Internal medicine. The author has an hindex of 9, co-authored 13 publications.
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Papers
Estrogen-related receptor γ is a key regulator of muscle mitochondrial activity and oxidative capacity
Shamina M. Rangwala,Xiaomei Wang,Jennifer A. Calvo,Loren Lindsley,Yunyu Zhang,Galina Deyneko,Valerie Beaulieu,Jiaping Gao,Gordon M. Turner,Judit Markovits +9 more
TL;DR: The data indicate that ERRγ plays an important role in causing a shift toward slow twitch muscle type and, concomitantly, a greater capacity for endurance exercise, and it is demonstrated that a small molecule agonist of ERRβ/γ can increase mitochondrial function in mouse myotubes.
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The effect of 1,3-diaryl-[1H]-pyrazole-4-acetamides on glucose utilization in ob/ob mice
Gregory Raymond Bebernitz,Greg Argentieri,Beverly Battle,Christine M. Brennan,Bork Balkan,Bryan Burkey,Michele Eckhardt,Jiaping Gao,Prasad Koteswara Kapa,Robert J. Strohschein,Herbert F. Schuster,Mary Wilson,Xu David +12 more
TL;DR: Evidence of a new class of compounds, 1,3-diaryl-[1H]-pyrazole-4-acetamides, initially identified from their ability to increase glucose transport in an adipocyte and muscle cell line and ultimately demonstrating dramatic glucose lowering in ob/ob mice, a diabetic animal model is provided.
156
Secondary Amides of (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase
Thomas Daniel Aicher,Robert C. Anderson,Jiaping Gao,Suraj S. Shetty,Gary M. Coppola,James L. Stanton,Douglas C. Knorr,Donald Mark Sperbeck,Leonard J. Brand,Christine C. Vinluan,Emma L. Kaplan,Carol J. Dragland,Tomaselli Hc,A. Islam,R. J. Lozito,Xilin Liu,Wieslawa Maniara,William S. Fillers,Dominick DelGrande,R. E. Walter,William R. Mann +20 more
TL;DR: Methyl substitution of the piperazine at the 2- and 5-positions markedly increased the potency of the lead compound (>1,000-fold) and oral bioavailability of the compounds in this series is good and is optimal when the 4-position of thepiperazine is substituted with an electron-poor benzoyl moiety.
85
Substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones as hypoglycemic agents.
Thomas Daniel Aicher,Bork Balkan,Philip A. Bell,Leonard J. Brand,Cheon Seung Hoon,Rhonda O. Deems,Fell Jay Bradford,William S. Fillers,Fraser James D,Jiaping Gao,Douglas C. Knorr,Gerald G. Kahle,Christina L. Leone,Jeffrey Nadelson,Ronald Simpson,Howard C. Smith +15 more
TL;DR: The synthesis and evaluation of a series of isoxazoles and other monocyclic compounds were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes and SDZ 25a(2S) (SDZ PGU 693) was selected for further pharmacological studies.
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Diet-induced modulation of mitochondrial activity in rat muscle.
TL;DR: Although the muscle mitochondrial system may initially offer enough compliance to counteract lipid surplus, these in vivo data suggest a vicious long-term cycle among mitochondrial dysfunction, IMCL accumulation, and glucose intolerance in the rat.
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