Jiapeng Wang
Indiana University
10 Papers
88 Citations
Jiapeng Wang is an academic researcher from Indiana University. The author has contributed to research in topics: Myeloid & Haematopoiesis. The author has an hindex of 8, co-authored 10 publications. Previous affiliations of Jiapeng Wang include University of South Carolina.
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Papers
Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice.
Jiapeng Wang,Zhaomin Li,Yongzheng He,Feng Pan,Feng Pan,Shi Chen,Steven D. Rhodes,Lihn Nguyen,Jin Yuan,Li Jiang,Xianlin Yang,Ophelia Weeks,Ziyue Liu,Jiehao Zhou,Hongyu Ni,Chen-Leng Cai,Mingjiang Xu,Feng Chun Yang +17 more
TL;DR: The authors showed that deletion of Asxl1 in mice led to developmental abnormalities including dwarfism, anophthalmia, and 80% embryonic lethality, and they also developed mild MDS-like disease, which could progress to MDS/myeloproliferative neoplasm.
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Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells
Feng Pan,Feng Pan,Feng Pan,Thomas S. Wingo,Thomas S. Wingo,Zhigang Zhao,Rui Gao,Hideki Makishima,Guangbo Qu,Guangbo Qu,Li Lin,Miao Yu,Janice Ortega,Jiapeng Wang,Aziz Nazha,Li Chen,Bing Yao,Can Liu,Shi Chen,Ophelia Weeks,Hongyu Ni,Brittany L. Phillips,Suming Huang,Jianlong Wang,Chuan He,Guo Min Li,Tomas Radivoyevitch,Iannis Aifantis,Jaroslaw P. Maciejewski,Feng Chun Yang,Feng Chun Yang,Peng Jin,Mingjiang Xu,Mingjiang Xu +33 more
TL;DR: In this paper, the authors show that Tet2-/- mice develop spontaneous myeloid, T- and B-cell malignancies after long latencies, and that the increased mutational burden is particularly high at genomic sites that gained 5-hydroxymethylcytosine, where TET2 normally binds.
Bone marrow NG2+/Nestin+ mesenchymal stem cells drive DTC dormancy via TGF-β2
Ana Rita Nobre,Ana Rita Nobre,Emma Risson,Emma Risson,Deepak K. Singh,Julie Di Martino,Julie F. Cheung,Jiapeng Wang,John A. Johnson,Hege G. Russnes,Jose Javier Bravo-Cordero,Alexander Birbrair,Alexander Birbrair,Bjørn Naume,Bjørn Naume,Mohamad Azhar,Paul S. Frenette,Julio A. Aguirre-Ghiso +17 more
- 01 Mar 2021
TL;DR: The results provide direct proof that hematopoietic stem cell dormancy niches control BC DTC dormancy and suggest that aging or extrinsic factors that affect the NG2+/Nestin+ MSC niche homeostasis may result in a break from dormancies and BC bone relapse.
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Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells
Feng Pan,Feng Pan,Feng Pan,Thomas S. Wingo,Thomas S. Wingo,Zhigang Zhao,Rui Gao,Hideki Makishima,Guangbo Qu,Guangbo Qu,Li Lin,Miao Yu,Janice Ortega,Jiapeng Wang,Aziz Nazha,Li Chen,Bing Yao,Can Liu,Shi Chen,Ophelia Weeks,Hongyu Ni,Brittany L. Phillips,Suming Huang,Jianlong Wang,Chuan He,Guo Min Li,Tomas Radivoyevitch,Iannis Aifantis,Jaroslaw P. Maciejewski,Feng Chun Yang,Feng Chun Yang,Peng Jin,Mingjiang Xu,Mingjiang Xu +33 more
- 25 Apr 2017
TL;DR: It is shown that Tet2−/− mice develop spontaneous myeloid, T- and B-cell malignancies after long latencies, and Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells, suggesting a novel TET2 loss-mediated mechanism of haem atological malignancy pathogenesis.
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Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model.
Steven D. Rhodes,Xiaohua Wu,Yongzheng He,Shi Chen,Hao Yang,Karl Staser,Jiapeng Wang,Ping Zhang,Chang Jiang,Hiroki Yokota,Ruizhi Dong,Xianghong Peng,Xianlin Yang,Sreemala Murthy,Mohamad Azhar,Khalid S. Mohammad,Mingjiang Xu,Theresa A. Guise,Feng Chun Yang +18 more
TL;DR: In this article, the authors provide genetic and pharmacologic evidence that hyperactive TGFβ1 signaling pivotally underpins osseous defects in Nf1(flox/-) ;Col2.3Cre mice, a model which closely recapitulates the skeletal abnormalities found in the human disease.
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