Jianyu Yu
Ohio State University
8 Papers
3 Citations
Jianyu Yu is an academic researcher from Ohio State University. The author has contributed to research in topics: Immunotherapy & Medicine. The author has an hindex of 2, co-authored 3 publications. Previous affiliations of Jianyu Yu include Southern Medical University.
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Papers
Role of FABP5 in T Cell Lipid Metabolism and Function in the Tumor Microenvironment
TL;DR: In this paper , an emerging role of fatty acid binding protein 5 (FABP5), also known as epidermal FABP, or E-FABB), a cytosolic lipid chaperone, in facilitating fatty acid uptake, transport, and metabolism and regulating the differentiation and function of different T cell subsets.
•Journal Article
Is AAV-delivered IL-27 a potential immunotherapeutic for cancer?
Jin-Qing Liu,Jianmin Zhu,Aiyan Hu,Alaina Zhang,Chunbaixue Yang,Jianyu Yu,Kalpana Ghoshal,Sujit Basu,Xue-Feng Bai +8 more
TL;DR: The evidence that support these points are summarized and AAV-delivered IL-27 is proposed as a potential immunotherapeutic for cancer.
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CD200 Blockade Modulates Tumor Immune Microenvironment but Fails to Show Efficacy in Inhibiting Tumor Growth in a Murine Model of Melanoma.
TL;DR: In this paper, the authors evaluated the potential impacts of CD200 blockade in a more human relevant tumor model, and found that Yumm1.7 tumor cells with bone marrow derived macrophages (BMDM) from WT and CD200R-/- mice confirmed upregulation of macrophage CCL8.
IL-27 Induces CCL5 Production by T Lymphocytes, Which Contributes to Antitumor Activity
Aiyan Hu,Jianmin Zhu,Chunxi Zeng,Cho-Hao Lin,Jianyu Yu,Jin-Qing Liu,Kimberly Lynch,Fatemeh Talebian,Xueliang Pan,Jingyue Yan,Yizhou Dong,Zihai Li,Xue-Feng Bai +12 more
TL;DR: It is demonstrated that IL-27 directly induces CCL5 production by T lymphocytes, particularly CD8+ T cells in vitro and in vivo, which contributes to antitumor activity.
IL-27 Gene Therapy Induces Stat3-Mediated Expansion of CD11b+Gr1+ Myeloid Cells and Promotes Accumulation of M1 Macrophages in the Tumor Microenvironment.
Jianmin Zhu,Jianyu Yu,Aiyan Hu,Jin-Qing Liu,Gang Xin,William E. Carson,Zihai Li,Yiming Yang,Xue-Feng Bai +8 more
TL;DR: This article showed that IL-27 gene therapy induces Stat3-mediated expansion of CD11b+Gr1+ myeloid cells and promotes accumulation of M1 macrophages in the tumor microenvironment.
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