Jiansen Lu
Southern Medical University
14 Papers
Jiansen Lu is an academic researcher from Southern Medical University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 5 publications.
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Papers
Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2.
Haiyan Zhang,Chuangxin Lin,Chun Zeng,Zhenyu Wang,Hua Wang,Jiansen Lu,Xin Liu,Yan Shao,Chang Zhao,Jianying Pan,Song Xu,Yue Zhang,Denghui Xie,Daozhang Cai,Xiaochun Bai +14 more
TL;DR: The results show that promoting the macrophage M1 polarisation leads to exacerbation of experimental OA partially through secretion of Rspo2 and activation of β-catenin signalling in chondrocytes.
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Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone
Bin Huang,Wenhao Wang,Qingchu Li,Zhenyu Wang,Bo Yan,Zhongmin Zhang,Liang Wang,Minjun Huang,Chunhong Jia,Jiansen Lu,Sichi Liu,Hongdong Chen,Mangmang Li,Daozhang Cai,Yu Jiang,Dadi Jin,Xiaochun Bai +16 more
TL;DR: It is shown that Cxcl9 produced by osteoblasts interacts with vascular endothelial growth factor and prevents its binding to ECs and osteoblast, thus abrogating angiogenesis and osteogenesis both in mouse bone and in vitro.
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Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice.
Jiansen Lu,Haiyan Zhang,Daozhang Cai,Chun Zeng,Pinglin Lai,Yan Shao,Hang Fang,Delong Li,Jiayao Ouyang,Chang Zhao,Denghui Xie,Bin Huang,Jian Yang,Yu Jiang,Xiaochun Bai +14 more
TL;DR: A positive‐feedback regulation of H‐type vessel formation in subchondral bone by articular chondrocyte nutrient‐sensing mTORC1 signaling is essential for the pathogenesis and progression of OA.
74
Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways
Jiansen Lu,Hongbo Zhang,Jianying Pan,Zhiqiang Hu,Liangliang Liu,Yanli Liu,Xiao Yu,Bai Xiaochun,Daozhang Cai,Haiyan Zhang +9 more
TL;DR: This study showed that fargesin switched the polarized phenotypes of macrophages from M1 to M2 subtypes and prevented cartilage degeneration partially by down-regulating p38/ERK MAPK and p65/NF-κB signaling and targeting macrophage reprogramming or blocking the crosstalk between macrophaging and chondrocytes in early OA may be an effective preventive strategy.
Activation of cGAS‐STING by Lethal Malaria N67C Dictates Immunity and Mortality through Induction of CD11b+Ly6Chi Proinflammatory Monocytes
Yang Du,Yien Luo,Zhiqiang Hu,Jiansen Lu,Xin Liu,Changsheng Xing,Jian Wu,Tianhao Duan,Junjun Chu,Helen Yicheng Wang,Xin-zhuan Su,Xiao Yu,Rongfu Wang +12 more
TL;DR: These findings identify a previously unrecognized detrimental role of cGAS‐STING‐MyD88‐p38 axis in infectious diseases through triggering the late IL‐6 production and proinflammatory monocyte expansion and provide insight into how targeting the DNA sensing pathway, dysregulated cytokines, and pro inflammatory monocytes enhances immunity against infection.
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