Jianping Yuan
Harvard University
14 Papers
54 Citations
Jianping Yuan is an academic researcher from Harvard University. The author has contributed to research in topics: Immune system & Tumor microenvironment. The author has an hindex of 11, co-authored 14 publications. Previous affiliations of Jianping Yuan include Second Military Medical University & Shanghai Jiao Tong University.
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Papers
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy
Yuhui Huang,Jianping Yuan,Elda Righi,Walid S. Kamoun,Marek Ancukiewicz,Jean Nezivar,Michael Santosuosso,John D. Martin,Margaret R. Martin,Fabrizio Vianello,Pierre Leblanc,Lance L. Munn,Peigen Huang,Dan G. Duda,Dai Fukumura,Rakesh K. Jain,Mark C. Poznansky +16 more
TL;DR: It is demonstrated that targeting tumor vasculature with lower vascular-normalizing doses, but not high antivascular/antiangiogenic doses, of an anti-VEGF receptor 2 (VEGFR2) antibody results in a more homogeneous distribution of functional tumor vessels.
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CXCL12/CXCR4 Blockade Induces Multimodal Antitumor Effects That Prolong Survival in an Immunocompetent Mouse Model of Ovarian Cancer
Elda Righi,Satoshi Kashiwagi,Jianping Yuan,Michael Santosuosso,Pierre Leblanc,Rachel Ingraham,Benjamin Forbes,Beth Edelblute,Brian Collette,Deyin Xing,Magdalena Kowalski,Magdalena Kowalski,Maria Cristina Mingari,Fabrizio Vianello,Michael J. Birrer,Sandra Orsulic,Sandra Orsulic,Glenn Dranoff,Mark C. Poznansky +18 more
TL;DR: Modulation of the CXCL12/CXCR4 axis in ovarian cancer has multimodal effects on tumor pathogenesis associated with induction of antitumor immunity and offers a definitive preclinical validation of CX CR4 as a therapeutic target in this disease.
Coxsackievirus B3-induced apoptosis and Caspase-3
TL;DR: It is proposed that CVB3 may induce apoptosis and necrosis in HeLa cells, the latter appearing much earlier than previously proposed, and caspase-3 inhibitor can not decrease DNA fragmentation.
A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma
Jianping Yuan,Satoshi Kashiwagi,Patrick Reeves,Jean Nezivar,Yuan Yang,Nadiah Hashim Arrifin,Mai Nguyen,Gilberte Jean-Mary,Xiaoyun Tong,Paramjit Uppal,Korochkina Svetlana E,Ben Forbes,Tao Chen,Elda Righi,Roderick T. Bronson,Huabiao Chen,Sandra Orsulic,Timothy Brauns,Pierre Leblanc,Nathalie Scholler,Glenn Dranoff,Glenn Dranoff,Jeffrey A. Gelfand,Mark C. Poznansky +23 more
TL;DR: Use of this bifunctional fusion protein in both mouse models significantly enhanced survival and slowed tumor growth while augmenting tumor-specific CD8+ T-cell dependent immune responses.
AMD3100 Augments the Efficacy of Mesothelin-Targeted, Immune-Activating VIC-008 in Mesothelioma by Modulating Intratumoral Immunosuppression
Binghao Li,Binghao Li,Yang Zeng,Patrick Reeves,Chongzhao Ran,Qiuyan Liu,Xiying Qu,Yingying Liang,Zhao Liu,Jianping Yuan,Pierre Leblanc,Zhaoming Ye,Ann E. Sluder,Jeffrey A. Gelfand,Timothy Brauns,Huabiao Chen,Mark C. Poznansky +16 more
TL;DR: It is shown that combination therapy significantly suppressed tumor growth and prolonged animal survival in two mouse models and was associated with loss of PTEN due to oxidative inactivation, highlighting the enhanced antitumor effect of AMD3100 in combination with a tumor antigen–targeted therapy in mouse malignant mesothelioma.