Jianjun Bao
National Institutes of Health
4 Papers
112 Citations
Jianjun Bao is an academic researcher from National Institutes of Health. The author has contributed to research in topics: MYH10 & Myosin. The author has an hindex of 4, co-authored 4 publications.
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Papers
Vertebrate Nonmuscle Myosin II Isoforms Rescue Small Interfering RNA-induced Defects in COS-7 Cell Cytokinesis
TL;DR: It is shown that expression of endogenous NMHC II-C in COS-7 cells is insufficient for normal cytokinesis and that exogenous NM HC II-A and NMHCII-C can, at least partially, rescue the defect in cytokineresis due to the loss of NMHC III-B.
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Replacement of nonmuscle myosin II-B with II-A rescues brain but not cardiac defects in mice.
TL;DR: In this article, the authors used homologous recombination to ablate nonmuscle myosin heavy chain (NMHC) II-B by inserting cDNA encoding green fluorescent protein (GFP)-NMHC II-A into the first coding exon of the Myh10 gene.
103
The B2 Alternatively Spliced Isoform of Nonmuscle Myosin II-B Lacks Actin-Activated MgATPase Activity and in Vitro Motility
TL;DR: The actin-activated MgATPase activity of a chimeric HMM with the 21-amino acid II-B2 sequence inserted into the homologous location in the heavy chain of HMM II-C is increased following MLC-20 phosphorylation, which indicates that the effect of the II- B2 insert is myosin heavy chain specific.
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Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated mice.
TL;DR: Interestingly, the mesh-like structure and patency of the spinal canal can be restored by increasing expression of the motor-impaired NM II-B, which also rescues hydrocephalus, thereby preventing hydrocephalu during mouse brain development.