Jianing Wu
5 Papers
Jianing Wu is an academic researcher. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 3, co-authored 3 publications.
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Papers
Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage
TL;DR: The development of sustained-release drug delivery systems (DDSs) for OA may be an attractive strategy to prevent rapid drug clearance and improve the half-life of a drug at the joint cavity to promote the development of effective OA drugs in the future.
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Opsonized nanoparticles target and regulate macrophage polarization for osteoarthritis therapy: A trapping strategy.
Longfa Kou,Huirong Huang,Ying Zhong Tang,Meng Sun,Yingtao Li,Jianing Wu,Shimin Zheng,Xin Zhao,Daosen Chen,Zucheng Luo,Xiaolei Zhang,Qing Yao,Ruijie Chen +12 more
TL;DR: In this paper , a novel opsonization trapping strategy for osteoarthritis drug delivery and treatment is proposed, which transforms a normal nanoparticle into an opsonized attractant to target and regulate macrophage polarization.
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Opsonization Inveigles Macrophages Engulfing Carrier-Free Bilirubin/JPH203 Nanoparticles to Suppress Inflammation for Osteoarthritis Therapy.
Huirong Huang,Shimin Zheng,Jianing Wu,Xindan Liang,Shengjie Li,Pengfei Mao,Zhinan He,Yahui Chen,Lining Sun,Xin Zhao,Aimin Cai,Luhui Wang,Huixiang Sheng,Qing Yao,Ruijie Chen,Yingzheng Zhao,Longfa Kou +16 more
TL;DR: An immunoglobulin G-conjugated bilirubin/JPH203 self-assembled nanoparticle (IgG/BRJ) is developed and its therapeutic potential for OA is evaluated, and suppression of the inflammatory environment by IgG/BRJ promotes cartilage protection and repair in an OA rat model, thereby improving therapeutic outcomes.
17
Modulation of glucose metabolism through macrophage-membrane-coated metal-organic framework nanoparticles for triple-negative breast cancer therapy
Qing Yao,Jinyao Ye,Yahui Chen,Lihui Huang,Lining Sun,Zhinan He,Jianing Wu,Yingyi Zhao,Xin Zhao,Aimin Cai,Xiandan Chen,Hailun Zheng,Aliaksei Sysa,Congying Xie,Ruijie Chen,Longfa Kou +15 more
TL;DR: Researchers developed macrophage-membrane-coated metal-organic framework nanoparticles to deliver atorvastatin and polydatin, disrupting glucose metabolism in triple-negative breast cancer cells, inducing acidosis and oxidative stress, and sensitizing treatment.
11
A study of the antibacterial mechanism of pinocembrin against multidrug-resistant Aeromonas hydrophila
Yuru Wu,Jiehao Chen,Wenyan Wei,Yujia Miao,C. Liang,Jianing Wu,Xiaoli Huang,Lizi Yin,Yi Geng,Defang Chen Chen,Pin Ouyang +10 more
TL;DR: Pinocembrin is a candidate drug for the treatment of A. hydrophila infection in aquaculture by increasing cell membrane permeability and affecting protein and DNA metabolism and its mechanism of action was identified by investigating its effect on protein andDNA.