Jianguo Wang
Brigham and Women's Hospital
56 Papers
595 Citations
Jianguo Wang is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Tissue factor & Medicine. The author has an hindex of 25, co-authored 48 publications. Previous affiliations of Jianguo Wang include Chinese Academy of Sciences & University of Minnesota.
Chat about Author
Papers
Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer.
Alok A. Khorana,Charles W. Francis,Keon Menzies,Jianguo Wang,Ollivier Hyrien,James J. Hathcock,Nigel Mackman,Mark B. Taubman +7 more
TL;DR: TF was measured in samples obtained from patients with locally advanced or metastatic pancreatic cancer enrolled in a prospective trial conducted by the University of Rochester Community Clinical Oncology Program and hypothesized that elevated circulating levels of TF would be associated with development of VTE in pancreaticcancer.
309
Factor XIII activity mediates red blood cell retention in venous thrombi
Maria M. Aleman,James R. Byrnes,Jianguo Wang,Reginald Tran,Wilbur A. Lam,Jorge Di Paola,Nigel Mackman,Jay L. Degen,Matthew J. Flick,Alisa S. Wolberg +9 more
TL;DR: It is determined that activity of the transglutaminase factor XIII (FXIII) is critical for rbc retention within clots and directly affects thrombus size and identify FXIII as a potential therapeutic target for limiting venous thrombosis.
Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer.
Jianguo Wang,Julia E. Geddings,Maria M. Aleman,Jessica C. Cardenas,Pichika Chantrathammachart,Julie C. Williams,Daniel Kirchhofer,Vladimir Y. Bogdanov,Ronald R. Bach,Janusz Rak,Frank C. Church,Alisa S. Wolberg,Rafal Pawlinski,Nigel S. Key,Jen Jen Yeh,Nigel Mackman +15 more
TL;DR: The results of the present study using a xenograft mouse model suggest that tumor TF activates coagulation, whereas TF on circulating MPs may trigger venous thrombosis.
191
Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice
Rafal Pawlinski,Jianguo Wang,A. Phillip Owens,Julie C. Williams,Silvio Antoniak,Michael Tencati,Thomas Luther,Jesse W. Rowley,Elizabeth N. Low,Andrew S. Weyrich,Nigel Mackman +10 more
TL;DR: It is demonstrated that in a mouse model of endotoxemia activation of the coagulation cascade is initiated by TF expressed by myeloid cells and an unidentified nonhematopoietic cell type(s).
182
Monocyte tissue factor–dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin
A. Phillip Owens,Freda Passam,Silvio Antoniak,Stephanie M. Marshall,Allison L. McDaniel,Lawrence L. Rudel,Julie C. Williams,Brian K. Hubbard,Julie Ann Dutton,Jianguo Wang,Peter S. Tobias,Linda K. Curtiss,Alan Daugherty,Daniel Kirchhofer,James P. Luyendyk,Patrick M. Moriarty,Shanmugam Nagarajan,Barbara C. Furie,Bruce Furie,Douglas G. Johns,Ryan E. Temel,Nigel Mackman +21 more
TL;DR: In this paper, it was shown that hypercholesterolemia leads to elevated levels of oxidized LDL (oxLDL) in plasma and that this induces expression of the procoagulant protein tissue factor (TF) in monocytes.