30 Papers
43 Citations
Jiang Yu is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: PDZ domain & Whistler. The author has an hindex of 8, co-authored 8 publications.
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Papers
Human protein-disulfide isomerase is a redox-regulated chaperone activated by oxidation of domain a'
TL;DR: Both the chaperone activity and the overall conformation of human PDI are redox-regulated, and the structure of the reduced bb′xa′ reveals for the first time that domain a′ packs tightly with both domain b′ and linker x to form one compact structural module.
135
The INAD Scaffold Is a Dynamic, Redox-Regulated Modulator of Signaling in the Drosophila Eye
TL;DR: The results show that scaffolding proteins can actively modulate the intrinsic redox potentials of their disulfide bonds to exert regulatory roles in signaling.
73
Lipid-Induced Conformational Switch Controls Fusion Activity of Longin Domain SNARE Ykt6
Wenyu Wen,Jiang Yu,Lifeng Pan,Zhiyi Wei,Jingwei Weng,Wenning Wang,Yan Shan Ong,Ton Hoai Thi Tran,Wanjin Hong,Mingjie Zhang,Mingjie Zhang +10 more
TL;DR: It is demonstrated that unlipidated Ykt6 adopts multiple conformations, with a small population in the closed state, and that the posttranslationally attached farnesyl group can actively regulate Ykt 6 fusion activity in addition to its anticipated membrane-anchoring role.
45
Structural basis of the myosin X PH1N-PH2-PH1C tandem as a specific and acute cellular PI(3,4,5)P3 sensor
TL;DR: The first PH domain of the myosin X cargo-binding domain is split into halves by insertion of another PH domain forming a PH1N-PH2-PH1C tandem forming a rigid supramodule with the two lipid-binding pockets juxtaposed for cooperative binding to PI(3,4,5)P3-containing lipid membranes.
Diffuse auroral precipitation driven by lower-band chorus second harmonics
TL;DR: In this article , the authors show that the lower-band chorus alone can only cause the precipitation of electrons greater than 4 keV, while the self-consistently generated second harmonic is weak but still able to result in the electron precipitation below 4 kV.