18 Papers
121 Citations
Jian Yan is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Gene & Gene expression. The author has an hindex of 9, co-authored 18 publications. Previous affiliations of Jian Yan include University of Memphis & Brigham and Women's Hospital.
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Papers
Carbonic anhydrase-related protein VIII deficiency is associated with a distinctive lifelong gait disorder in waddles mice.
Yan Jiao,Jian Yan,Yu Zhao,Leah Rae Donahue,Wesley G. Beamer,Xin-Min Li,Bruce A. Roe,Mark S. LeDoux,Weikuan Gu +8 more
TL;DR: Data indicate that the wdl mouse is a Car8 null mutant and that CAR8 plays a central role in motor control.
133
A single nucleotide mutation in Nppc is associated with a long bone abnormality in lbab mice
Yan Jiao,Jian Yan,Feng Jiao,Hong Bin Yang,Leah Rae Donahue,Xin-Min Li,Bruce A. Roe,John M. Stuart,Weikuan Gu +8 more
TL;DR: A single nucleotide mutation of Nppc is associated with dwarfism in lbab/lbab mice and is a useful model for hereditary human achondroplasia.
A deletion causing spontaneous fracture identified from a candidate region of mouse Chromosome 14
Yan Jiao,Xin-Min Li,Wesley G. Beamer,Jian Yan,Yiai Tong,Dan Goldowitz,Bruce A. Roe,Weikuan Gu +7 more
TL;DR: The data demonstrated the feasibility to positionally clone the mutated gene from a non-fine-mapped locus, which has applicability to the positional cloning of genes from many other animal models, as their genome sequences are sequenced or will be sequenced soon.
28
Effects of carbonic anhydrase VIII deficiency on cerebellar gene expression profiles in the wdl mouse
Jian Yan,Yan Jiao,Feng Jiao,John M. Stuart,Leah Rae Donahue,Wesley G. Beamer,Xin-Min Li,Bruce A. Roe,Mark S. LeDoux,Weikuan Gu +9 more
TL;DR: Genes involved in signaling, cell division, zinc ion-binding, synapse integrity and plasticity were downregulated and several of the upregulated genes encode proteins that function in the Golgi apparatus which suggests that Car8 deficiency has important effects on synaptic vesicle formation and transport.
15
Differential gene expression between wild-type and Gulo-deficient mice supplied with vitamin C.
Yan Jiao,Jifei Zhang,Jian Yan,John M. Stuart,Griffin Gibson,Lu Lu,Robert Willaims,Yongjun Wang,Weikuan Gu +8 more
TL;DR: Test the hypothesis that hepatic vitamin C levels in VC deficient mice rescued with high doses of VC supplements still do not reach the optimal levels present in wild-type mice by using a mouse scurvy model, and found that Hepatic VC concentrations in MT mice were significantly lower than in WT mice.