Jian X. Wu
University of Copenhagen
18 Papers
128 Citations
Jian X. Wu is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Crystallization & Crystal growth. The author has an hindex of 13, co-authored 17 publications.
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Papers
Influence of solvent evaporation rate and formulation factors on solid dispersion physical stability.
TL;DR: The present study showed the applicability of the Quality by Design approach in solid dispersion research, and highlights the need for multifactorial analysis.
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Particle size dependence of polymorphism in spray-dried mannitol
TL;DR: Spray-drying of mannitol based formulations can result in variation in the solid state composition ofMannitol as a function of particle size, which may be clinically relevant and underlines the need for proper process control of inhalable dry powder produced by spray-dries.
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Impact of PLGA molecular behavior in the feed solution on the drug release kinetics of spray dried microparticles
Feng Wan,Jian X. Wu,Adam Bohr,Adam Bohr,Stefania Baldursdottir,Morten Jonas Maltesen,Simon Bjerregaard,Camilla Foged,Jukka Rantanen,Mingshi Yang +9 more
TL;DR: In this article, the impact of the poly (lactic-co-glycolic acid) (PLGA) molecular behavior in the feed solution on the drug release kinetics of PLGA microparticles prepared via spray drying was analyzed.
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Influence of temperature on solvent-mediated anhydrate-to-hydrate transformation kinetics.
Haiyan Qu,Haiyan Qu,Tommy Munk,Claus Cornett,Jian X. Wu,Johan Bøtker,Lars Porskjær Christensen,Jukka Rantanen,Fang Tian +8 more
TL;DR: A deeper understanding of the underlying principle of the acceleration and deceleration effects of temperature on the phase transformation of anhydrate-to-hydrate phase transformation has been achieved.
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A case study of real-time monitoring of solid-state phase transformations in acoustically levitated particles using near infrared and Raman spectroscopy.
Sönke Rehder,Jian X. Wu,J. Laackmann,J. Laackmann,Hans-Ulrich Moritz,Jukka Rantanen,Thomas Rades,Thomas Rades,Claudia S. Leopold +8 more
TL;DR: It was concluded that acoustic levitation with NIR and Raman spectroscopy combined with multivariate curve resolution allowed direct determination of the recrystallisation kinetics of amorphous drugs and thus is a promising technique for monitoring solid-state phase transformations of adhesive small-sized samples during the early phase of drug development.
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