Jian Wang
Dalian Medical University
6 Papers
23 Citations
Jian Wang is an academic researcher from Dalian Medical University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 2, co-authored 4 publications.
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Papers
Chlorpyrifos Induces MLL Translocations Through Caspase 3-Dependent Genomic Instability and Topoisomerase II Inhibition in Human Fetal Liver Hematopoietic Stem Cells
Chengquan Lu,Xiaohui Liu,Chang Liu,Jian Wang,Chunna Li,Qi Liu,Yachen Li,Shuangyue Li,Shu Sun,Jinsong Yan,Jing Shao +10 more
TL;DR: Exposure to 10 μM CPF led to decrease in viability, inhibition in proliferation and induction of DNA double-strand breaks (DSBs) and occurrence of MLL(+) rearrangements, which indicates that in utero injury of CD34(+)HSC by CPF may contribute to the increased risk of infant leukemia.
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Elucidating the molecular mechanisms of perfluorooctanoic acid-serum protein interactions by structural mass spectrometry.
Wenxiang Zhang,Marin de La Rochefoucauld,Wenxiang Zhang,Zheyi Liu,Federico Ruozzi,Ye Zhou,Can Lai,Can Lai,Binwen Sun,Binwen Sun,Min He,Min He,Ziyang Zhai,Jian Wang,Qi Wang,Xian Wang,Fangjun Wang,Fangjun Wang,Yuanjiang Pan +18 more
TL;DR: In this article, an integrated structural strategy was developed to systematically profile the molecular details of dynamic interactions among PFOA, SA, and β-cyclodextrin (β-CD) by combing native mass spectrometry (nMS), lysine reactivity profiling (LRP), and molecular docking (MD) simulation.
1
Sodium houttuyfonate effectively treats acute pulmonary infection of Pseudomonas aeruginosa by affecting immunity and intestinal flora in mice
Tian Zhuang,M. Hu,Jian Wang,Long Mei,Xiaoxiao Zhu,Haitao Zhang,Fenyu Jin,Jing Shao,Tianming Wang,Changhong Wang,Xiaojia Niu,Daqiang Wu +11 more
TL;DR: In this article , a mouse pneumonia model induced by Pseudomonas aeruginosa nasal drip was used to explore the therapeutic effects of sodium houttuyfonate (SH) against P. aerruginosa infection in vivo.
DNA damage and repair in the hematopoietic system
Niu Li,Hongzhu Chen,Jian Wang +2 more
TL;DR: The impact of various types of DNA damage on HSC function is summarized and the knowledge of the corresponding repair mechanisms and related human genetic diseases is reviewed.