Jian Chen
Harbin Medical University
7 Papers
1 Citations
Jian Chen is an academic researcher from Harbin Medical University. The author has contributed to research in topics: Reactive oxygen species & Biology. The author has an hindex of 5, co-authored 6 publications.
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Papers
Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo
Xuyun Zhao,Li Gy,Yupeng Liu,Chai Lm,Jian Chen,Yan-Qiu Zhang,Zhimin Du,Yanjie Lu,Bao-Feng Yang +8 more
TL;DR: The present study evaluated the effects of resveratrol on As2O3‐induced apoptosis and cardiac injury and found it to be safe and effective.
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Exogenous H2S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Yu Sun,Fanghao Lu,Xiangjing Yu,Bingzhu Wang,Jian Chen,Fangping Lu,Shuo Peng,Xiaojiao Sun,Miao Yu,He Chen,Yan Wang,Linxue Zhang,Ning Liu,Haining Du,Dechao Zhao,Weihua Zhang +15 more
TL;DR: It is found that exogenous H2S could improve cardiac functions, reduce mitochondrial fragments and ROS levels, enhance mitochondrial respiration chain activities and inhibit mitochondrial apoptosis in the hearts of db/db mice.
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Lycopene alleviates di(2-ethylhexyl) phthalate-induced splenic injury by activating P62-Keap1-NRF2 signaling.
TL;DR: In this paper , a total of 140 mice were randomly divided into seven groups (n = 20) and continuously gavaged with corn oil, distilled water, DEHP (500 or 1000 mg/kg BW/day) and/or Lycopene (5 mg/k BW/d) for 28 days.
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Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice
Yu Sun,Zongyan Teng,Xiaojiao Sun,Linxue Zhang,Jian Chen,Bingzhu Wang,Fangping Lu,Ning Liu,Miao Yu,Shuo Peng,Yan Wang,Dechao Zhao,Yajun Zhao,Huan Ren,Zhongyi Cheng,Shiyun Dong,Fanghao Lu,Weihua Zhang +17 more
TL;DR: It is concluded that exogenous H2S plays a critical role in improving cardiac mitochondrial function in diabetes by upregulating SIRT3.
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Exogenous H2S Induces Hrd1 S-sulfhydration and Prevents CD36 Translocation via VAMP3 Ubiquitylation in Diabetic Hearts.
Miao Yu,Haining Du,Bingzhu Wang,Jian Chen,Fangping Lu,Shuo Peng,Yu Sun,Ning Liu,Xiaojiao Sun,Dong Shiyun,Yajun Zhao,Yan Wang,Dechao Zhao,Fanghao Lu,Weihua Zhang +14 more
TL;DR: It is suggested that H2S regulates VAMP3 ubiquitylation via Hrd1 S-sulfhydration at Cys115 to prevent CD36 translocation in diabetes.
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