Jian Chen
Fudan University
15 Papers
25 Citations
Jian Chen is an academic researcher from Fudan University. The author has contributed to research in topics: Virus & Medicine. The author has an hindex of 5, co-authored 12 publications.
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Papers
AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling
Jian Chen,Yi-feng Yang,Yu Yang,Peng Zou,Jun Chen,He Yongquan,Sai-lan Shui,Yan-ru Cui,Ru Bai,Ya-jun Liang,Yunwen Hu,Biao Jiang,Lu Lu,Xiaoyan Zhang,Xiaoyan Zhang,Jia Liu,Jianqing Xu,Jianqing Xu +17 more
TL;DR: It is shown that AXL is shown to inhibit type I interferon responses elicited by astrocyte infection in a STAT-dependent manner, enabling virus replication.
148
Efficacy and safety of CD24Fc in hospitalised patients with COVID-19: a randomised, double-blind, placebo-controlled, phase 3 study
James A. Welker,Carlos D Malvestutto,Olivia K. Giddings,Ella Li,Jian Chen,Kun He,Davis Gates,Amarjot Kaur,Jamie Chen,Martin Devenport,Raymond Touomou,Shyam Kottilil,Yang Liu,Pan Zheng,Yang Liu,Hung-Yen Chou,Jai Thakor,I. Khan,Nicole Bright Do,Josephine Faragalla,Andrea Hook,Sarah Kern,Janira V. Ramos,J. Ward,J. C. Higson,Meena Dam,Dawn Serkin,Pooja Karloopia,W. Moore,Mark Scofield,David J. Childers,Jeffrey S. Cantrell,Millie Corgan,Xiang Zhou,Jing Liu,Denise Redvers-Higgins,Huatao Han,Jiyun Hou,Yu-bin Pan,Karyn Tucker,Xiaoyan Zhang,Joel V Chua,Jennifer Husson,S. Narayanan,Jaqueline Bran,Ka Wing J. Lam,Alicia Jeffrey,Jennie Pexa,Mario Becerra,James Welker,Kathleen Gray,Nicole Richmond,C. O. Nzelibe,Susan L. Koletar,Mahdee Sobhanie,Jason Clark,Zihai Li,Kelsi Reynolds,K. Chakravarthy,Kevin Weller,M. Yusuf,Jennifer Severing,Kelley Barley,J. D. Pulido,Jennifer C. Fulton,William Gil,M.D. Jeanine,Richmond R.N.,Sandy Jones,Kristina Clemmer,Dana Byrne,Lisa Pedroza,E. Davidson,Amanda Logan,Katie Grant,Eric D. Whitman,Jason S. Kessler,Robert Roland,Rosemary Stefiniw,M. Maurer,Salome Geene,C. F. Buck,Debra Connolly,Patrice Light,Sunanda Baviskar,Y.W. Low,Krzysztof A. Michalski,Pamela Giordano,Jennifer Chao,Michelle Williams,A K Makkapati,Andrew T. Catanzaro,Jonathan Cohen,Mehad Musbah,Pramila Jaladanki,Ying Yuan,Shilpa Rele,Desirae Stewart,Starlet Lewis,I. Sankar,Nabulungi Kasumba,Kaylia Biney,E. Hekmat,Jordan E. Lake,Bindu Akkanti,Melissa J. Reimer-McAtee,Marisel Negret Hernandez +106 more
- 01 Mar 2022
TL;DR: CD24Fc is generally well tolerated and accelerates clinical improvement of hospitalised patients with COVID-19 who are receiving oxygen support and suggests that targeting inflammation in response to tissue injuries might provide a therapeutic option for patients hospitalised with CO VID-19.
28
Correlation Between Early Plasma Interleukin 37 Responses With Low Inflammatory Cytokine Levels and Benign Clinical Outcomes in Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Ang Li,Yun Ling,Zhigang Song,Xiaobo Cheng,Longfei Ding,Ren-Di Jiang,Weihui Fu,Yan Liu,Huiliang Hu,Songhua Yuan,Jian Chen,Cuisong Zhu,Jun Fan,Jing Wang,Yanling Jin,Miaomiao Zhang,Lingyan Zhu,Peng Sun,Linxia Zhang,Ran Qin,Wei Zhang,Chenli Qiu,Yinzhong Shen,Lin Zhang,Zhengli Shi,Chen Zhao,Tongyu Zhu,Hongzhou Lu,Xiaoyan Zhang,Jianqing Xu +29 more
TL;DR: IL-37 plays a protective role by antagonizing inflammatory responses while retaining type I IFN, thereby maintaining the functionalities of vital organs in patients infected with SARS-CoV-2.
IFN-κ suppresses the replication of influenza A viruses through the IFNAR-MAPK-Fos-CHD6 axis
He Yongquan,Weihui Fu,Kangli Cao,Qian He,Xiangqing Ding,Jian Chen,Lingyan Zhu,Tianyue Chen,Longfei Ding,Yu Yang,Cuisong Zhu,Songhua Yuan,Zejun Li,Chen Zhao,Xiaoyan Zhang,Xiaoyan Zhang,Jianqing Xu,Jianqing Xu +17 more
TL;DR: Using a mouse model of influenza A virus infection, IFN-κ was one of the earliest responding type I IFNs after infection with H9N2, a low-pathogenic avian influenza Airus, whereas this early induction did not occur upon infection with the epidemic-causing H7N9 virus.
21
Immune Signature of Enhanced Functional Avidity CD8+ T Cells in vivo Induced by Vaccinia Vectored Vaccine.
Zhidong Hu,Lingyan Zhu,Jing Wang,Yanmin Wan,Songhua Yuan,Jian Chen,Xiangqing Ding,Chenli Qiu,Xiaoyan Zhang,Chao Qiu,Jianqing Xu +10 more
TL;DR: CD8+ T cells of high functional avidity induced in vivo by VACV are characterized, which not only improves the understanding of adaptive T cell immunity in VacV vaccination, but also provides clues to modulatefunctional avidity of CD8- T cells for T cell based immunotherapy.