Jiale Wu
Shanghai Jiao Tong University
15 Papers
2 Citations
Jiale Wu is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 6 publications.
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Papers
Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.
Shuo Chen,Jiale Wu,Ying Liang,Yigang Tang,Huaxin Song,Li-Li Wu,Yang-Fei Xing,Ni Yan,Yuntong Li,Zhengyuan Wang,Shu-Jun Xiao,Xin Lu,Sai-Juan Chen,Min Lu +13 more
TL;DR: Arsenic trioxide (ATO) has been shown to stabilize the DNA-binding loop-sheet-helix motif alongside the overall β-sandwich fold, endowing p53 mutants with thermostability and transcriptional activity as discussed by the authors.
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Diverse rescue potencies of p53 mutations to ATO are predetermined by intrinsic mutational properties
Huaxin Song,Jiale Wu,Yigang Tang,Yuting Dai,Xinrong Xiang,Ya Li,Lili Wu,Ying Liang,Yangfei Xing,Ni Yan,Yuntong Li,Zhengyuan Wang,Shujun Xiao,Jiabing Li,Derun Zheng,Xin-Jie Chen,Hai-Jun Fang,Chenjing Ye,Yuting Ma,Yu Wu,Wen Wu,Junming Li,Su-Jiang Zhang,Min Lu +23 more
TL;DR: Song et al. as mentioned in this paper evaluated 800 common p53 mutants for their rescue potencies by the representative generic rescue compound arsenic trioxide (ATO) in terms of transactivation activity, cell growth inhibition, and mouse tumor-suppressive activities.
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Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations.
Yigang Tang,Huaxin Song,Zhengyuan Wang,Shujun Xiao,Xinrong Xiang,Hui-En Zhan,Lili Wu,Jiale Wu,Yangfei Xing,Yun Tan,Ying Liang,Ni Yan,Yuntong Li,Jiabing Li,Jiaqi Wu,Derun Zheng,Yu-Long Jia,Zhiming Chen,Yunqi Li,Qianqian Zhang,Jianmin Zhang,Hui Zeng,Weiyang Tao,Yu Wu,Min Lu +24 more
TL;DR: In this article , a rational screening identified antiparasitic drug potassium antimony tartrate (PAT) as an agent that can thermostabilize the representative temperature-sensitive (TS) mutant p53-V272M via noncovalent binding.
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Developmental arsenic exposure impairs cognition, directly targets DNMT3A, and reduces DNA methylation
Ni Yan,Yuntong Li,Yangfei Xing,Jiale Wu,Jiabing Li,Ying Liang,Yigang Tang,Zhengyuan Wang,Huaxin Song,Haoyu Wang,Shujun Xiao,Min Lu +11 more
TL;DR: Treatment with metformin, a first‐line antidiabetic agent reported to increase DNA methylation, ameliorates the behavioral deficits and normalizes the aberrant expression of cognition‐related genes andDNA methylation in the hippocampus of arsenic‐exposed offspring.
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Three optimized assays for the evaluation of compounds that can rescue p53 mutants
Jiale Wu,Huaxin Song,Zhengyuan Wang,Min Lu +3 more
- 04 Jun 2021
TL;DR: Three easily accessible assays are suggested to determine the thermostability, protein folding, and transcriptional activity of p53 mutants—the go-to criteria for evaluating a rescue compound that acts by increasing p53 ther mostability.
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