Jiake He
China Pharmaceutical University
14 Papers
90 Citations
Jiake He is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Pharmacokinetics & Chemistry. The author has an hindex of 7, co-authored 11 publications.
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Papers
Effects of SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of repaglinide in healthy Chinese volunteers
Jiake He,Zhixia Qiu,Ning Li,Yang Yu,Yang Lu,Deen Han,Tingting Li,Di Zhao,Wei Sun,Fang Fang,Jianheng Zheng,Hongwei Fan,Xijing Chen +12 more
TL;DR: SLCO1B1*1B /*1B/*1B genotype is associated with reduced pharmacokinetic exposure after a single dose oral administration of 2 mg repaglinide, including decreased AUC0-∞ and increased clearance of repaglinside.
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Simultaneous determination of six phenolic constituents of Danshen injection in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study
TL;DR: A rapid, sensitive and specific liquid chromatographic–electrospray ionization–mass spectrometry method for the simultaneous quantitative determination of these compounds in rat plasma was developed and successfully applied to a pharmacokinetic study in rats after an intravenous administration of Danshen injection.
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Mitochondria-mediated Ferroptosis in Diseases Therapy: From Molecular Mechanisms to Implications.
Fuhai Feng,Shasha He,Xiaoling Li,Jiake He,Lianxiang Luo +4 more
TL;DR: A comprehensive overview of how mitochondria contribute to ferroptosis in different conditions, including cancer, cardiovascular disease, inflammatory disease, mitochondrial DNA depletion syndrome, and novel coronavirus pneumonia is presented.
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Comparative pharmacokinetic studies of racemic oxiracetam and its pure enantiomers after oral administration in rats by a stereoselective HPLC method.
Qiuyang Zhang,Wei Yang,Yue Yang,Han Xing,Qing Zhang,Junxiu Li,Yang Lu,Jiake He,Shuoye Yang,Di Zhao,Xijing Chen +10 more
TL;DR: The higher absorption and slower elimination suggest that enantiopure (S)-ORC could be a promising drug that efficiently reduces clinical dosage, improves therapeutic indices, decreases toxicology risks, and results in increased therapeutic ration.
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Enantioselective HPLC determination of oxiracetam enantiomers and application to a pharmacokinetic study in beagle dogs.
Qiuyang Zhang,Wei Yang,Qing Zhang,Yue Yang,Junxiu Li,Yang Lu,Yi Zheng,Jiake He,Di Zhao,Xijing Chen +9 more
TL;DR: An enantioselective high-performance liquid chromatography method was developed and validated for the determination of oxiracetam enantiomers, a cognition and memory enhancer, in beagle dog plasma and was successfully applied to a pharmacokinetic study of individual enantiomer and racemic oxir acetam in beagles dogs after oral administration.
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