The Achilles tendon (AT) is responsible for running, jumping, and standing. The AT injuries are very common in the population. In the adult population (21–60 years), the incidence of AT injuries is approximately 2.35 per 1,000 people. It negatively impacts people’s quality of life and increases the medical burden. Due to its low cellularity and vascular deficiency, AT has a poor healing ability. Therefore, AT injury healing has attracted a lot of attention from researchers. Current AT injury treatment options cannot effectively restore the mechanical structure and function of AT, which promotes the development of AT regenerative tissue engineering. Various nanofiber-based scaffolds are currently being explored due to their structural similarity to natural tendon and their ability to promote tissue regeneration. This review discusses current methods of AT regeneration, recent advances in the fabrication and enhancement of nanofiber-based scaffolds, and the development and use of multiscale nanofiber-based scaffolds for AT regeneration.

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

The present work is focused on the nano-Hydroxyapatite (nHAp) synthesis with two different Indian breed Aseel and Kadaknath eggshells. The alloplast implants were developed through the foam replica method with polyurethane 45-PPI as a porous template. The synthesized nHAp was characterized by Field Emission Scanning Electron Microscopy (FE-SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The FE-SEM images of the nHAp showed the one dimensional clustered nanoparticles and the X-ray diffraction spectrum confirms that the major phase was hydroxyapatite with a small trace of β-tricalcium phosphate. The maximum compression strength of the sample was 5.49 ± 0.12 MPa which is in the range of the compression strength of human trabecular bone. The thermal and degradability studies results confirmed that these are highly stable and provides necessary a resorption needed for new bone tissue formation. Besides, the antimicrobial activity against tested human microbiome are satisfactory and the cell viability towards MG 63 human osteoblast-like cells provides a potential pathway for developing the nHAp implants for bone tissue engineering. 

Processing and characterization of egg shell derived nano-hydroxyapatite synthetic bone for Orthopaedic and Arthroscopy implants and substitutes in dentistry.

Multifunctional coatings of phenolic phytocompounds of medical interest: Assembly methods and applications

Dual-jet electrospun PDLGA/PCU nonwovens as promising mesh implant materials with controlled release of sirolimus and diclofenac.

Nowadays, 3D printing has become a popular method among surgeons due to its merits in orthopedic treatments. In this method, polymeric biomaterials are deposited in a layer-by-layer manner to fabricate 3D objects that can be used as orthopedic implants and plates; however, 3D-printed implants or plates may lack properties required to bond with host tissue. Coating surface of plates with nano-fibers is an appropriate way to modify plates to overcome this challenge. In this study, first, an orthopedic plate was 3D printed with Polylactic acid (PLA) and coated with polycaprolactone (PCL)/Akermanite (AKT) nano-fibers. The composition included 8 wt.% of PCL and 3 wt.% of nAKT, while diameter of the PCL/AKT nano-fibers was approximately 253 nm ± 33 nm. Thermomechanical properties such as pressure, three-point bending flexural, and thermal conductivity of coated and non-coated specimens were examined and compared. In the next step, the bioactivity of the coated samples was evaluated following a 28-day immersion in simulated body fluid (SBF). Further, scanning electron microscope (SEM) images were taken to assess morphology of nanofibers and apatite formation on samples. By adding PCL to PLA, the maximum pressure force is enhanced by 16.83%. Further by adding nAKT to PLA+PCL sample, the maximum pressure force is enhanced by 4.72%. Further, by adding PCL to PLA, the maximum bending flexural force is enhanced by 21.06%. Further by adding nAKT to PLA+PCL sample, the maximum bending flexural force is enhanced by 21.39%. The results of this study are used to improve modeling of the orthopedic plates. 

Thermomechanical properties of coated PLA-3D-printed orthopedic plate with PCL/Akermanite nano-fibers: Experimental procedure and AI optimization

Enhanced bone tissue regeneration via bioactive electrospun fibrous composite coated titanium orthopedic implant.

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Enhanced bone tissue regeneration via bioactive electrospun fibrous composite coated titanium orthopedic implant.