26 Papers
5 Citations
Jia Sun is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Medicine & Neuropathic pain. The author has an hindex of 10, co-authored 17 publications.
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Papers
Pharmacological inhibition of the NLRP3 inflammasome as a potential target for cancer-induced bone pain.
Shu-Ping Chen,Ya-Qun Zhou,Xiao-Mei Wang,Jia Sun,Fei Cao,Fei Cao,Salem HaiSam,Da-Wei Ye,Yu-Ke Tian +8 more
TL;DR: Chronic administration with MCC950 restored the protein expression of NLRP3 inflammasome and significantly suppressed the upregulation of IL-1β, which might be a novel therapeutic target for treatment of CIBP.
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Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain
Ya-Qun Zhou,Dai-Qiang Liu,Shu-Ping Chen,Nan Chen,Jia Sun,Xiao-Mei Wang,Fei Cao,Yu-Ke Tian,Da-Wei Ye +8 more
TL;DR: It is shown that a single dose of Nrf2 activator, oltipraz, dose-dependently attenuated established mechanical allodynia in PINP rats and demonstrate that oltIPraz ameliorates PINP via activating NRF2/HO-1-signaling pathway in the spinal cord.
Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK/PGC-1α-mediated mitochondrial biogenesis and suppression of neuroinflammation
Jia Sun,Fan-He Song,Jiayi Wu,Long-Qing Zhang,Dan-Yang Li,Shao-Jie Gao,Dai-Qiang Liu,Ya-Qun Zhou,Wei Mei +8 more
TL;DR: In this paper , the role of Sesn2 in osteoarthritis (OA) pain and delineated the underlying molecular mechanisms in the L4-6 spinal cord was examined.
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Minocycline as a promising therapeutic strategy for chronic pain
TL;DR: The results from the lab and others suggest that minocycline exerts strong analgesic effect in animal models of chronic pain including visceral pain, chemotherapy-induced periphery neuropathy, periphery injury induced neuropathic pain, diabetic neuropathicPain, spinal cord injury, inflammatory pain and bone cancer pain.
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DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation
Long-Qing Zhang,Shao-Jie Gao,Jia Sun,Dan-Yang Li,Jiayi Wu,Fan-He Song,Dai-Qiang Liu,Ya-Qun Zhou,Wei Mei +8 more
TL;DR: In this article , the effects of intrathecal injection of recombinant DKK3 (rDKK3) on mechanical allodynia and microglial activation in the spinal cord after spared nerve injury (SNI) in rats by western blot, immunofluorescence (IF), quantitative polymerase chain reaction (qPCR), and enzyme-linked immunosorbent assay (ELISA).
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