Jia Cheng
Rockefeller University
26 Papers
28 Citations
Jia Cheng is an academic researcher from Rockefeller University. The author has contributed to research in topics: NMDA receptor & Hippocampal formation. The author has an hindex of 16, co-authored 26 publications. Previous affiliations of Jia Cheng include University at Buffalo.
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Papers
Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators
Lara J. Duffney,Ping Zhong,Jing Wei,Emmanuel Matas,Jia Cheng,Luye Qin,Kaijie Ma,David M. Dietz,Yuji Kajiwara,Joseph D. Buxbaum,Zhen Yan +10 more
TL;DR: It is found that Shank3-deficient mice exhibit autism-like social deficits and repetitive behaviors, as well as the significantly diminished NMDA receptor (NMDAR) synaptic function and synaptic distribution in prefrontal cortex, and targeting actin regulators provides a strategy for autism treatment.
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Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease.
Yan Zheng,Yan Zheng,Aiyi Liu,Aiyi Liu,Zi-Jun Wang,Qing Cao,Wei Wang,Lin Lin,Kaijie Ma,Freddy Zhang,Jing Wei,Emmanuel Matas,Jia Cheng,Guojun Chen,Xiaomin Wang,Zhen Yan +15 more
TL;DR: The results suggest that disrupted epigenetic regulation of glutamate receptor transcription underlies the synaptic and cognitive deficits in Alzheimer's disease, and targeting histone methylation enzymes may represent a novel therapeutic strategy for this prevalent neurodegenerative disorder.
142
Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons.
Markus Riessland,Benjamin Kolisnyk,Tae Wan Kim,Jia Cheng,Jason Ni,Jordan A. Pearson,Emily J. Park,Kevin Dam,Devrim Acehan,Lavoisier Ramos-Espiritu,Wei Wang,Jack Zhang,Jae-Won Shim,Gabriele Ciceri,Lars Brichta,Lorenz Studer,Paul Greengard +16 more
TL;DR: The data implicate senescence of dopamine neurons as a contributing factor in the pathology of Parkinson's disease because SATB1 directly represses expression of the pro-senescence factor p21 in dopaminergic neurons.
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Shank3 Deficiency Induces NMDA Receptor Hypofunction via an Actin-Dependent Mechanism
TL;DR: Results suggest that Shank3 deficiency induces NMDAR hypofunction by interfering with the Rac1/PAK/cofilin/actin signaling, leading to the loss of N MDAR membrane delivery or stability.
114
HCN2 Channels in Cholinergic Interneurons of Nucleus Accumbens Shell Regulate Depressive Behaviors
TL;DR: It is found that the expression and function of the hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) are decreased in ChIs of NAc shell in depressed mice, suggesting that enhancement of HCN2 channel activity in NAc ChIs is a feasible approach for the development of a new class of antidepressants.
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