Jhalak Singhal
University of Delhi
14 Papers
2 Citations
Jhalak Singhal is an academic researcher from University of Delhi. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Jhalak Singhal include International Centre for Genetic Engineering and Biotechnology.
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Papers
Suppression of TLR2-Induced IL-12, Reactive Oxygen Species, and Inducible Nitric Oxide Synthase Expression by Mycobacterium tuberculosis Antigens Expressed inside Macrophages during the Course of Infection
Deepti Gupta,Sachin Sharma,Jhalak Singhal,Akash Tripathi Satsangi,Cecil Antony,Krishnamurthy Natarajan +5 more
TL;DR: M. tuberculosis genes, expressed inside infected macrophages as a function of time, collectively suppress protective immune responses by using multiple and complementary mechanisms.
55
Suppression of Dendritic Cell-mediated Responses by Genes in Calcium and Cysteine Protease Pathways during Mycobacterium tuberculosis Infection
Jhalak Singhal,Neha Agrawal,Mohit Vashishta,N. Gayatri Priya,Brijendra K Tiwari,Yogendra Singh,Rajagopal Raman,Krishnamurthy Natarajan +7 more
TL;DR: RNAi-mediated knockdown of genes in dendritic cells identified unreported genes and pathways that regulate its various functions during Mycobacterium tuberculosis infection that could be potential targets in drug and vaccine designing.
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Reciprocal Regulation of Reactive Oxygen Species and Phospho-CREB Regulates Voltage Gated Calcium Channel Expression during Mycobacterium tuberculosis Infection
Arti Selvakumar,Cecil Antony,Jhalak Singhal,Brijendra K Tiwari,Yogendra Singh,Krishnamurthy Natarajan +5 more
TL;DR: A dynamic reciprocal cross-regulation between ROS and pCREB was observed that in turn governed VGCC expression with ROS playing a limiting role in the process.
Targeting Artemisinin-Resistant Malaria by Repurposing the Anti-Hepatitis C Virus Drug Alisporivir
Ayushi Chaurasiya,Geeta Kumari,S. Garg,Rumaisha Shoaib,Zille Anam,Nishant Joshi,Jyoti Kumari,Jhalak Singhal,N. Singh,Shikha Kaushik,Amandeep Kaur Kahlon,Neha Dubey,Mukesh Maurya,Pallavi Srivastava,Manisha Marothia,P. Joshi,Kanika Gupta,Savita Saini,Gobardhan Das,Souvik Bhattacharjee,Shailja K. J. Singh,Anand Ranganathan +21 more
TL;DR: In this paper , the authors reported the rational repurposing of the anti-hepatitis C virus drug, alisporivir, a nonimmunosuppressive analog of cyclosporin A, against artemisinin-resistant strains of P. falciparum.
9
Host inducible-HSP70A1A is an irresistible drug target to combat SARS-CoV2 infection and pathogenesis
P. Joshi,S. Garg,Shailendra Mani,Kamini Jakhar,Manisha Marothia,Rumaisha Shoaib,Shreeja Biswas,Jhalak Singhal,Ankita Behl,Amandeep Kaur Kahlon,Maxim Shevtsov,Pramod Garg,Shailja K. J. Singh,Anand Ranganathan +13 more
TL;DR: In this article , the authors demonstrate that the SARS-CoV-2 virus exploits the host HSP70 chaperone for its entry and propagation and blocking it can combat the infection.