Jesús Ogando
Spanish National Research Council
5 Papers
17 Citations
Jesús Ogando is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: CD8 & T cell. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Jesús Ogando include University of the Basque Country.
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Papers
PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8+ T lymphocytes
Jesús Ogando,María Eugenia Sáez,Javier Santos,Cristina Nuevo-Tapioles,Marta Gut,Anna Esteve-Codina,Simon Heath,Antonio González-Pérez,José M. Cuezva,Rosa Ana Lacalle,Santos Mañes +10 more
TL;DR: Although PD-1-stimulated cells showed severe cristae alterations, assembly of respiratory supercomplexes was unexpectedly greater in these cells than in activated T cells, suggesting that mitochondria are the main targets ofPD-1 inhibitory activity.
Notch-regulated miR-223 targets the aryl hydrocarbon receptor pathway and increases cytokine production in macrophages from rheumatoid arthritis patients
Jesús Ogando,Manuel Tardaguila,Andrea Díaz-Alderete,Alicia Usategui,Vanessa Miranda-Ramos,Dannys Jorge Martinez-Herrera,Lorena de la Fuente,María J. García-León,María Carmen Bellver Moreno,Sara Escudero,Juan D. Cañete,María L. Toribio,Ildefonso Cases,Alberto Pascual-Montano,José L. Pablos,Santos Mañes +15 more
TL;DR: The results associate Notch signalling to miR-223 downregulation in RA macrophages, and identify miR -223 as a negative regulator of the AHR/ARNT pathway through ARNT targeting.
Involvement of lipid droplets in hepatic responses to lipopolysaccharide treatment in mice
Lino Arisqueta,Maitane Nuñez-Garcia,Jesús Ogando,Itsaso Garcia-Arcos,Begoña Ochoa,Patricia Aspichueta,Olatz Fresnedo,Yuri Rueda +7 more
TL;DR: The results suggest that altered hepatic management of LD lipids in LPS-treated mice might be related to the channeled mobilization of triacylglycerol for very low density lipoprotein assembly and to the induction of cholesterol export.
16
A flow cytometry-based method to screen for modulators of tumor-specific T cell cytotoxicity
TL;DR: This work describes a simple, sensitive method, based on flow cytometry analyses, to quantitatively measure cytotoxicity in vitro, and provides examples that validate its feasibility and specificity using CD8+ T lymphocytes specific for a surrogate tumor antigen, and a blocking antibody for the inhibitory PD-1/PD-L1 axis.
2
Diacylglycerol kinase α inactivation is an integral component of the costimulatory pathway that amplifies TCR signals.
Javier Arranz-Nicolás,Jesús Ogando,Denise Soutar,Raquel Arcos-Pérez,Daniel Meraviglia-Crivelli,Santos Mañes,Isabel Mérida,Antonia Ávila-Flores +7 more
TL;DR: It is demonstrated that pharmacological inhibition of DGKα downstream of the TCR provides a gain-of-function effect that amplifies the DAG-dependent signaling cascade, an ability that could be exploited therapeutically to reinvigorate T cells to attack tumors.