Jesus Arcos
Ohio State University
17 Papers
18 Citations
Jesus Arcos is an academic researcher from Ohio State University. The author has contributed to research in topics: Biology & Immune system. The author has an hindex of 13, co-authored 17 publications.
Chat about Author
Papers
CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions.
Stephanie A. Amici,Nicholas A. Young,Janiret Narvaez-Miranda,Kyle A. Jablonski,Jesus Arcos,Lucia E. Rosas,Tracey L. Papenfuss,Jordi B. Torrelles,Wael N. Jarjour,Mireia Guerau-de-Arellano +9 more
TL;DR: It is established that CD38 transcript and protein are robustly induced in human macrophages exposed to LPS (±IFN-γ) inflammatory stimuli, but not with the alternative stimulus, IL-4, which is consistent with an inflammatory marker role for CD38 in human Macrophages and monocytes.
Characterization of Host and Microbial Determinants in Individuals with Latent Tuberculosis Infection Using a Human Granuloma Model
Evelyn Guirado,Uchenna Mbawuike,Tracy L. Keiser,Jesus Arcos,Abul K. Azad,Shu-Hua Wang,Larry S. Schlesinger +6 more
TL;DR: An in vitro granuloma model derived from blood cells of individuals with latent TB infection that more accurately defines the human immune response and metabolic profiles of M. tuberculosis within this uniquely regulated immune environment is developed.
121
Human Lung Hydrolases Delineate Mycobacterium tuberculosis–Macrophage Interactions and the Capacity To Control Infection
Jesus Arcos,Smitha J. Sasindran,Nagatoshi Fujiwara,Joanne Turner,Larry S. Schlesinger,Jordi B. Torrelles +5 more
TL;DR: This work identified and measured several hydrolases in human alveolar lining fluid and lung tissue that dramatically modified the M. tuberculosis cell envelope, and found that the cell envelope-modifying effects of the hydrolase also led to altered M.culosis intracellular trafficking and induced a protective proinflammatory response to infection.
Entrapment of H1N1 Influenza Virus Derived Conserved Peptides in PLGA Nanoparticles Enhances T Cell Response and Vaccine Efficacy in Pigs
Jagadish Hiremath,Kyung-il Kang,Ming Xia,Mohamed Elaish,Basavaraj Binjawadagi,Kang Ouyang,Santosh Dhakal,Jesus Arcos,Jordi B. Torrelles,Xi Jiang,Chang-Won Lee,Gourapura J. Renukaradhya +11 more
TL;DR: It is indicated that nanoparticle-mediated delivery of conserved H1N1 influenza peptides induced the virus specific T cell response in the lungs and reduced the challenged heterologous virus load in the airways of pigs.
Mycobacterium tuberculosis cell wall released fragments by the action of the human lung mucosa modulate macrophages to control infection in an IL-10-dependent manner
Jesus Arcos,Smitha J. Sasindran,Juan I. Moliva,Julia M. Scordo,Sabeen Sidiki,H Guo,P Venigalla,Holden V. Kelley,G Lin,Lauren E. Diangelo,S N Silwani,J Zhang,Joanne Turner,Jordi B. Torrelles +13 more
TL;DR: It is demonstrated that ALF hydrolases, at their physiological concentrations and upon contact with M.tb, release M.Tb cell envelope fragments that are bioactive, but non-cytotoxic, regulate the function of macrophages, and thus are capable of modulating the immune response contributing to the control of M. tb infection through innate immune modulation.
47