Jessie E. Buth
University of California, Los Angeles
10 Papers
8 Citations
Jessie E. Buth is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Biology & Organoid. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Jessie E. Buth include Center for Autism and Related Disorders.
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Papers
Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection
Momoko Watanabe,Jessie E. Buth,Neda Vishlaghi,Luis de la Torre-Ubieta,Jiannis Taxidis,Baljit S. Khakh,Giovanni Coppola,Caroline A. Pearson,Ken Yamauchi,Danyang Gong,Xinghong Dai,Robert Damoiseaux,Roghiyh Aliyari,Simone Liebscher,Katja Schenke-Layland,Katja Schenke-Layland,Katja Schenke-Layland,Christine Caneda,Christine Caneda,Eric J. Huang,Ye Zhang,Ye Zhang,Genhong Cheng,Daniel H. Geschwind,Peyman Golshani,Ren Sun,Bennett G. Novitch +26 more
TL;DR: Optimized organoid culture methods are described that efficiently and reliably produce cortical and basal ganglia structures similar to those in the human fetal brain in vivo and are demonstrated for modeling the teratogenic effects of Zika virus on the developing brain and identifying more susceptibility receptors and therapeutic compounds that can mitigate its destructive actions.
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25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model
Chunfeng Li,Yong-Qiang Deng,Shuo Wang,Feng Ma,Feng Ma,Roghiyh Aliyari,Xing-Yao Huang,Na-Na Zhang,Momoko Watanabe,Hao-Long Dong,Ping Liu,Xiaofeng Li,Qing Ye,Min Tian,Shuai Hong,Junwan Fan,Hui Zhao,Lili Li,Neda Vishlaghi,Jessie E. Buth,Connie Au,Ying Liu,Ning Lu,Peishuang Du,F. Xiao-Feng Qin,Bo Zhang,Danyang Gong,Xinghong Dai,Ren Sun,Bennett G. Novitch,Zhiheng Xu,Cheng-Feng Qin,Genhong Cheng,Genhong Cheng +33 more
TL;DR: It is demonstrated that cholesterol‐25‐hydroxylase (CH25H) was induced in response to ZikV infection and that its enzymatic product, 25‐hydroxycholesterol (25HC), was a critical mediator of host protection against ZIKV.
327
Treatment outcome of atypical EGFR mutations in the German National Network Genomic Medicine Lung Cancer (nNGM).
Melanie Janning,Juliane Süptitz,C. Albers-Leischner,P Delpy,Amanda Tufman,Janna-Lisa Velthaus-Rusik,Martin Reck,Alex Jung,Diego Kauffmann-Guerrero,Irina Bonzheim,Stephanie Brändlein,Horst Hummel,Marcel Wiesweg,H. U. Schildhaus,Jan Stratmann,M. Sebastian,Juergen Alt,Jessie E. Buth,I. Esposito,J. Berger,Lars Tögel,Felix C Saalfeld,Martin Wermke,Sabine Merkelbach-Bruse,Axel M. Hillmer,Frederick Klauschen,Carsten Bokemeyer,Reinhard Buettner,Jonathan Wolf,Sonja Loges +29 more
TL;DR: In this paper , a multicenter study of the national Network Genomic Medicine (nNGM) in Germany, 856 NSCLC cases with atypical EGFR mutations including co-occurring mutations were reported from 12 centers.
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TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids
Momoko Watanabe,Jessie E. Buth,Jillian R. Haney,Neda Vishlaghi,Felix B. Turcios,Lubayna S. Elahi,Wen Gu,Caroline A. Pearson,Arinnae Kurdian,Natella V. Baliaouri,Amanda J. Collier,Osvaldo A. Miranda,N. Dunn,Di Chen,Shan Sabri,L. torre-Ubieta,Amander T. Clark,Kathrin Plath,Heather R. Christofk,Harley I. Kornblum,Michael J. Gandal,Bennett G. Novitch +21 more
TL;DR: In this article , the authors demonstrate that a major contributor to cortical organoid quality is the way hPSCs are maintained prior to differentiation, and identify combinations of TGFβ-related growth factors that are necessary and together sufficient to impart broad telencephalic organoid competency to feeder-free hPSC and enhance the formation of well-structured brain tissues suitable for disease modeling.
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TGFβ superfamily signaling regulates the state of human stem cell pluripotency and competency to create telencephalic organoids
Momoko Watanabe,Momoko Watanabe,Jillian R. Haney,Jillian R. Haney,Neda Vishlaghi,Felix Turcios,Jessie E. Buth,Wen Gu,Amanda J. Collier,Osvaldo A. Miranda,Di Chen,Shan Sabri,Amander T. Clark,Kathrin Plath,Heather R. Christofk,Michael J. Gandal,Michael J. Gandal,Bennett G. Novitch +17 more
TL;DR: It is demonstrated that a major contributor to successful cortical organoid production is the manner in which hPSCs are maintained prior to differentiation, and combinations of TGFβ-related growth factors are identified sufficient to impart broad telencephalic organoid competency to feeder-free hPSCS and enable reproducible formation of brain structures suitable for disease modeling.