Jesse Donovan
Princeton University
13 Papers
7 Citations
Jesse Donovan is an academic researcher from Princeton University. The author has contributed to research in topics: RNase P & RNA. The author has an hindex of 10, co-authored 13 publications.
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Papers
Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response
TL;DR: In this paper, the authors reported 2.8 and 2.1 angstrom crystal structures of human RNase L in complexes with synthetic and natural ligands and a fragment of an RNA substrate.
Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line
Yize Li,Shuvojit Banerjee,Stephen A. Goldstein,Beihua Dong,Christina Gaughan,Sneha Rath,Jesse Donovan,Alexei Korennykh,Robert H. Silverman,Susan R. Weiss +9 more
TL;DR: It is demonstrated that ablation ofRNase L activity promotes survival of ADAR1 deficient cells even in the presence of MDA5 and MAVS, suggesting that the RNase L system is the primary sensor pathway for endogenous dsRNA that leads to cell death.
Rapid RNase L–driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery
TL;DR: By sequencing abundant RNA fragments generated by RNase L in human cells, this work identifies site-specific cleavage of two groups of noncoding RNAs: Y-RNAs, whose function is poorly understood, and cytosolic t RNAs, which are essential for translation.
Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3.
TL;DR: X-ray crystallography and biochemistry are used to demonstrate that human OAS1 and OAS3 recognize dsRNA molecules of different length, and show that domain duplication accompanied by a loss of catalytic activity provides the mechanism for sensing long ds RNA by HOAS3.
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A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation.
Samantha R. Oakes,Samantha R. Oakes,David Gallego-Ortega,David Gallego-Ortega,Prudence M Stanford,Simon Junankar,Simon Junankar,Wendy Wing Yee Au,Zoya Kikhtyak,Anita von Korff,Claudio M Sergio,Andrew M. K. Law,Lesley Castillo,Stephanie L. Allerdice,Adelaide I. J. Young,Catherine L. Piggin,Belinda Whittle,Edward M. Bertram,Matthew J. Naylor,Matthew J. Naylor,Daniel L. Roden,Daniel L. Roden,Jesse Donovan,Alexei Korennykh,Christopher C. Goodnow,Christopher C. Goodnow,Christopher C. Goodnow,Moira K O'Bryan,Christopher J. Ormandy,Christopher J. Ormandy +29 more
TL;DR: The identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development that caused post-partum failure of lactation in healthy mice with otherwise normally developed mammary glands.