Jerry Silver
Case Western Reserve University
206 Papers
2.4K Citations
Jerry Silver is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Axon & Glial scar. The author has an hindex of 78, co-authored 201 publications. Previous affiliations of Jerry Silver include Massachusetts Eye and Ear Infirmary & University of Virginia.
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Papers
Regeneration beyond the glial scar
Jerry Silver,Jared H. Miller +1 more
TL;DR: Chondroitin and keratan sulphate proteoglycans are among the main inhibitory extracellular matrix molecules that are produced by reactive astrocytes in the glial scar, and they are believed to play a crucial part in regeneration failure.
Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes
TL;DR: The inability of the adult glial scar tissue to support neurite outgrowth was best correlated with the expression of CS-PG and CT, suggesting that these molecules may be involved in limiting the growth of regenerating axons in the CNS after injury.
1.2K
CNS Injury, Glial Scars, and Inflammation: Inhibitory extracellular matrices and regeneration failure
Michael T. Fitch,Jerry Silver +1 more
TL;DR: Other strategies for modulating inflammation and changing the make up of inhibitory molecules in the extracellular matrix are providing robust evidence that rehabilitation after spinal cord and brain injury has the potential to significantly change the outcome for what was once thought to be permanent disability.
1K
The Biology of Regeneration Failure and Success After Spinal Cord Injury.
TL;DR: The perineuronal net and how chondroitin sulfate proteoglycans deposited in both the glial scar and net impede axonal outgrowth at the level of the growth cone are discussed.
701
PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration
Yingjie Shen,Alan P. Tenney,Sarah A. Busch,Kevin P. Horn,Fernando X. Cuascut,Kai Liu,Zhigang He,Jerry Silver,John G. Flanagan +8 more
TL;DR: It is shown that a transmembrane protein tyrosine phosphatase, PTPσ, binds with high affinity to neural CSPGs and may provide new therapeutic approaches to neural regeneration.
676