Abbreviations 2DG 2-Deoxy-D-glucose A10 RNA aptamer A10 2′-fluoropyrimidine RNA aptamer ACTH Adrenocorticotropin hormone CRF Corticotropin releasing factor CS Chitosan DCC N,N′-dicyclohexylcarbodiimide EDC 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride EPR Enhanced permeability and retention FOL Folic acid HER Human epidermal receptors MRI Magnetic resonance imaging NHS N-Hydroxysuccinimide PCL Poly(ε-caprolactone) PDGFR Platelet-derived growth factor receptor PEG Poly(ethylene glycol) PET Positron emission tomography PGA Poly(glycolic acid) PLA Poly(lactic acid) PLGA Poly(lactic-co-glycolic) PLL Poly(L-lysine) PSMA Prostate-specific membrane antigen siRNA Small interfering RNA SPECT Single photon emission computed tomography TPGS D-α-tocopheryl polyethylene glycol succinate VCAM-1 Vascular cell adhesion molecule-1 VEGFR Endothelial growth factor receptors WGA Wheat germ agglutinin

/pdf/strategies-to-target-tumors-using-nanodelivery-systems-based-1lde1y46ys.pdf

Strategies to target tumors using nanodelivery systems based on biodegradable polymers, aspects of intellectual property, and market

A delivery device for topical and systemic delivery of agents to targeted oral locations, such as mouth cancer cells, has been developed. The formulation includes a mucoadhesive polymeric matrix such as chitosan, which contains one or more therapeutic and/or diagnostic agents, taste masking agents, permeation enhancers, the therapeutic or diagnostic agent to be delivered, and a hydrophilic polymeric coating such as polyethyleneglycol ("PEG").

Targeted buccal delivery of agents

Described herein is a method of inducing vascular inflammation using modified paramagnetic nanoparticles with improved therapeutic loading efficiency and enhanced circulation properties. The method comprises loading lipophilic agent into the fatty acid coatings of a paramagnetic nanoparticle (PMNP). In certain embodiment, the lipophilic agent is lipopolysaccharides (LPS). Described herein is a method of inducing vascular leakiness. In certain embodiment, the method induces a significant enhancement of vascular leakiness in a human body. In certain embodiments, the vascular leakiness allows for enhanced local delivery of nanoparticle and non-nanoparticle based therapeutics, imaging agents and theranostics. Also described herein is a method of using the PMNP for the treatment of diseases. In certain embodiments, the method of treatment is a combination therapy. Described herein are imaging of therapeutic delivery of PMNP and diagnostic methods using the PMNP. Also described herein is a diagnostic kit that comprises the PMNP.

Modified paramagnetic nanoparticles for targeted delivery of therapeutics and methods thereof

The present invention relates to magnetic nanoparticles coated with block copolymers. The invention further relates to methods of increasing cellular uptake of magnetic nanoparticles and use of the coated magnetic particles to selectively kill cancer cells, treat cancer, detect cancer, and for biomedical imaging.

Magnetic Nanoparticle-Polymer Complexes and uses Thereof

The present invention is related to a radiolabeled active targeting pharmaceutical composition, including: a bioconjugate and a radionuclide, wherein the bioconjugate includes a biomolecule and a metal nanoparticle, wherein the biomolecule has an affinity for receptors on the surface of a cell membrane and is selected from the group consisting of a peptide and a protein The present invention further provides a method for evaluating a thermal adjuvant therapy for tumors and a kit thereof The above-mentioned pharmaceutical composition is applied to evaluate a tumor accumulation time, so as to establish the optimal policy for a radiofrequency- or laser-induced thermal adjuvant therapy for tumors

Radiolabeled active targeting pharmaceutical composition and the use thereof

The present invention provides methods of detecting a cancer cell in an individual, methods of grading a cancer, and methods of treating a cancer. The methods involve use of functionalized magnetic nanoparticles that comprise a moiety that provides for selective association with, and/or metabolic uptake into, a cancer cell.

Use of functionalized magnetic nanoparticles in cancer detection and treatment

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Use of functionalized magnetic nanoparticles in cancer detection and treatment