Jérôme Delamare
University of Caen Lower Normandy
6 Papers
46 Citations
Jérôme Delamare is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Radiosynthesis & Radioligand. The author has an hindex of 5, co-authored 6 publications.
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Papers
PET imaging with [18F]AV-45 in an APP/PS1-21 murine model of amyloid plaque deposition
Géraldine Poisnel,Martine Dhilly,Olivier Moustié,Jérôme Delamare,Ahmed Abbas,Denis Guilloteau,Louisa Barré +6 more
TL;DR: The possibility of [18F]AV-45, coupled with microPET, to visualize and quantitatively measure amyloid deposits in the brains of living APP/PS1 mice is opened.
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[11C]-MeJDTic: a novel radioligand for κ-opioid receptor positron emission tomography imaging
Géraldine Poisnel,Farhana Oueslati,Martine Dhilly,Jérôme Delamare,Cécile Perrio,Danièle Debruyne,Louisa Barré +6 more
TL;DR: Findings suggested that [(11)C]-MeJDTic appeared to be a promising selective "lead" radioligand for kappa-opioid receptor PET imaging.
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N-[18F]-FluoropropylJDTic for κ-opioid receptor PET imaging: Radiosynthesis, pre-clinical evaluation, and metabolic investigation in comparison with parent JDTic.
Sébastien Schmitt,Jérôme Delamare,Olivier Tirel,Fabien Fillesoye,Martine Dhilly,Cécile Perrio +5 more
TL;DR: Although the newly proposed radioligand [18F]9 was concluded to be not suitable for KOR PET imaging due to the formation of brain penetrating radiometabolites, the findings highlight the metabolic stability of JDTic and may help in the design of novel J DTic derivatives for in vivo applications.
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Automated radiosynthesis of [(18)F]ML-10, a PET radiotracer dedicated to apoptosis imaging, on a TRACERLab FX-FN module.
TL;DR: ML-10 was prepared on a widely available automated module and passed the quality control and a LC/MS method was developed to measure specific radioactivity.
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Synthesis and Biological Evaluation of N-Substituted Quinolinimides, as Potential Ligands for in Vivo Imaging Studies of δ-Opioid Receptors
Thomas Bourdier,Géraldine Poisnel,Martine Dhilly,Jérôme Delamare,Joël Henry,Danièle Debruyne,Louisa Barré +6 more
TL;DR: The syntheses of N-substituted quinolinimide derivatives displaying sufficient affinity and high selectivity for δ-opioid receptors are reported, among 9-subsituted derivatives, one showed much higher selectivity in binding assays than the δ antagonist methylnaltrindole.
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