Jens Wölfel
University of Zurich
3 Papers
20 Citations
Jens Wölfel is an academic researcher from University of Zurich. The author has contributed to research in topics: Synapse & Postsynaptic potential. The author has an hindex of 3, co-authored 3 publications.
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Papers
Coincident Pre- and Postsynaptic Activation Induces Dendritic Filopodia via Neurotrypsin-Dependent Agrin Cleavage
Kazumasa Matsumoto-Miyai,Ewa Sokolowska,Andreas Zurlinden,Christine E. Gee,Daniel Lüscher,Stefan Hettwer,Jens Wölfel,Ana Paula Ladner,Jeanne Ster,Urs Gerber,Thomas Rülicke,Beat Kunz,Peter Sonderegger +12 more
TL;DR: The activity-dependent formation of dendritic filopodia is abolished in hippocampal neurons from neurotrypsin-deficient mice and may be instrumental for a Hebbian organization and remodeling of synaptic circuits in the CNS.
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Purification and enzymological characterization of murine neurotrypsin
Raymond Reif,Susanne Sales,Birgit Dreier,Daniel Lüscher,Jens Wölfel,Claudio Gisler,Antonio Baici,Beat Kunz,Peter Sonderegger +8 more
TL;DR: Site-specific mutations of the amino acids flanking the scissile bonds showed that cleavage is highly specific and requires a basic amino acid preceded by a glutamate residue on the N-terminal side of the scISSile bond, which argues for a unique substrate binding pocket of neurotrypsin.
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Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation.
Raymond Reif,Susanne Sales,Stefan Hettwer,Birgit Dreier,Claudio Gisler,Jens Wölfel,Daniel Lüscher,Andreas Zurlinden,Alexander Stephan,Shaheen Ahmed,Antonio Baici,Birgit Ledermann,Beat Kunz,Peter Sonderegger +13 more
TL;DR: It is shown that agrin cleavage depends on neurotrypsin and occurs at two conserved sites, and dysregulation of agrin processing is a good candidate for a pathogenetic mechanism underlying mental retardation.