Jenna L. Voellinger
University of Washington
8 Papers
2 Citations
Jenna L. Voellinger is an academic researcher from University of Washington. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 4, co-authored 5 publications.
Chat about Author
Papers
Development of a microphysiological model of human kidney proximal tubule function
Elijah J. Weber,Alenka Chapron,Brian D. Chapron,Jenna L. Voellinger,Kevin A. Lidberg,Catherine K. Yeung,Zhican Wang,Yoshiyuki Yamaura,Dale W. Hailey,Thomas Neumann,Danny D. Shen,Kenneth E. Thummel,Kimberly A. Muczynski,Jonathan Himmelfarb,Edward J. Kelly +14 more
TL;DR: This microphysiological system can serve as an ideal platform for ex vivo modeling of renal drug clearance and drug-induced nephrotoxicity and can be used for preclinical screening of new chemical compounds prior to initiating human clinical trials.
240
Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity.
Shih-Yu Chang,Jenna L. Voellinger,Kirk P. Van Ness,Brian D. Chapron,Rachel M. Shaffer,Thomas Neumann,Charles L. White,Terrance J. Kavanagh,Edward J. Kelly,David L. Eaton +9 more
TL;DR: Results indicate that MPS-cultured hepatocytes provide a promising approach for evaluating chemical toxicity in vitro, and the utility of this model for acute hepatotoxicity assessment is demonstrated.
40
Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system
Edward J. Kelly,Zhican Wang,Jenna L. Voellinger,Cathy Yeung,Danny D. Shen,Kenneth E. Thummel,Ying Zheng,Giovanni Ligresti,David L. Eaton,Kimberly A. Muczynski,Jeremy S. Duffield,Thomas Neumann,Anna Tourovskaia,Mark E. Fauver,Greg Kramer,Elizabeth Asp,Jonathan Himmelfarb +16 more
TL;DR: This work plans to robustly model the human kidney tubule interstitium, utilizing an ex vivo three-dimensional modular microphysiological system with human kidney-derived cells, which should accurately reflect human physiology, be usable to predict renal handling of xenobiotics, and should assess mechanisms of kidney injury, and the biological response to injury, from endogenous and exogenous intoxicants.
Pharmacogenetic profiling and metabolic activity of human embryonic stem cell derived hepatocytes: focus on CYP450-mediated oxidation
TL;DR: Based on gene expression profiling, SCDHs most closely resemble fetal hepatocytes, especially with regards to AFP, CYP3A7 and FMO1 expression, and these studies indicate a low degree of genetic diversity of pharmacogenetically-relevant genes in the WiCell® hESC lines.
Population pharmacokinetic analysis for tisotumab vedotin in patients with locally advanced and/or metastatic solid tumors
Leonid Gibiansky,Chaitali Passey,Jenna L. Voellinger,Rudy Gunawan,William D. Hanley,Manish Gupta,Helen Winter +6 more
TL;DR: Body weight was the most influential covariate influencing distribution and elimination of ADC and MMAE, thus supporting weight‐based dosing of tisotumab vedotin.