Jemmie Cheng
Massachusetts Institute of Technology
5 Papers
Jemmie Cheng is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Promoter & HDAC3. The author has an hindex of 3, co-authored 5 publications. Previous affiliations of Jemmie Cheng include Picower Institute for Learning and Memory.
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Papers
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
Yuan-Ta Lin,Jinsoo Seo,Jinsoo Seo,Fan Gao,Heather M. Feldman,Hsin-Lan Wen,Jay Penney,Jay Penney,Hugh P. Cam,Hugh P. Cam,Elizabeta Gjoneska,Elizabeta Gjoneska,Waseem K. Raja,Waseem K. Raja,Jemmie Cheng,Jemmie Cheng,Richard Rueda,Oleg Kritskiy,Fatema Abdurrob,Zhuyu Peng,Blerta Milo,Chung Jong Yu,Sara Elmsaouri,Dilip Dey,Tak Ko,Bruce A. Yankner,Li-Huei Tsai,Li-Huei Tsai +27 more
TL;DR: Consistently, converting APOE4 to APOE3 in brain cell types from sAD iPSCs was sufficient to attenuate multiple AD-related pathologies and establishes a reference for human cell-type-specific changes associated with theAPOE4 variant.
965
Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.
Alexi Nott,Jemmie Cheng,Jemmie Cheng,Fan Gao,Fan Gao,Yuan-Ta Lin,Yuan-Ta Lin,Elizabeta Gjoneska,Elizabeta Gjoneska,Tak Ko,Tak Ko,Paras S. Minhas,Paras S. Minhas,Paras S. Minhas,Alicia V. Zamudio,Alicia V. Zamudio,Jia Meng,Jia Meng,Jia Meng,Feiran Zhang,Peng Jin,Li-Huei Tsai,Li-Huei Tsai +22 more
TL;DR: The data suggest thatHDAC3 interaction with MeCP2 positively regulates a subset of neuronal genes through FOXO deacetylation, and disruption of HDAC3 contributes to cognitive and social impairment.
Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior
Alexi Nott,Jemmie Cheng,Jemmie Cheng,Fan Gao,Fan Gao,Yuan-Ta Lin,Yuan-Ta Lin,Elizabeta Gjoneska,Elizabeta Gjoneska,Tak Ko,Tak Ko,Paras S. Minhas,Paras S. Minhas,Paras S. Minhas,Alicia V. Zamudio,Alicia V. Zamudio,Jia Meng,Jia Meng,Jia Meng,Feiran Zhang,Peng Jin,Li-Huei Tsai,Li-Huei Tsai +22 more
- 01 Jul 2016
TL;DR: In this paper, the authors found that deletion of Hdac3 in mice elicited abnormal locomotor coordination, sociability and cognition, and showed that HDAC3 positively regulated a subset of genes and was recruited to active gene promoters via MeCP2.
Patent
Targeting the hdac2-sp3 complex to enhance synaptic function
Li-Huei Tsai,Hidekuni Yamakawa,Jemmie Cheng,Fan Gao,Jay Penney +4 more
- 12 Jul 2018
TL;DR: In this paper, a histone deacetylase 2 (HDAC2)/Sp3 inhibitor was used to treat a neurodegenerative disease in a subject using a peptide inhibitor comprising the carboxyl-terminus of HDAC2, and related compositions.
The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons
Hidekuni Yamakawa,Hidekuni Yamakawa,Jemmie Cheng,Jemmie Cheng,Jay Penney,Jay Penney,Fan Gao,Fan Gao,Richard Rueda,Richard Rueda,Jun Wang,Jun Wang,Satoko Yamakawa,Satoko Yamakawa,Oleg Kritskiy,Oleg Kritskiy,Elizabeta Gjoneska,Elizabeta Gjoneska,Li-Huei Tsai,Li-Huei Tsai +19 more
TL;DR: In this paper, an integrative genomics approach was used to identify proteins that mediate HDAC2 recruitment to synaptic plasticity genes, and the results indicated that targeting the HDAC-Sp3 complex could enhance cognitive function without affecting HDAC 2 function in other processes.