Jeffry Florian
Center for Drug Evaluation and Research
57 Papers
380 Citations
Jeffry Florian is an academic researcher from Center for Drug Evaluation and Research. The author has contributed to research in topics: Medicine & Pharmacodynamics. The author has an hindex of 16, co-authored 43 publications. Previous affiliations of Jeffry Florian include Food and Drug Administration.
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Papers
Effect of Sunscreen Application Under Maximal Use Conditions on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.
Murali K. Matta,Robbert Zusterzeel,Nageswara Rao Pilli,Vikram Patel,Donna A. Volpe,Jeffry Florian,Luke Oh,Edward D. Bashaw,Issam Zineh,Carlos Sanabria,Sarah Kemp,Anthony Godfrey,Steven Adah,Sergio G. Coelho,Jian Wang,Lesley Anne Furlong,Charles J. Ganley,Theresa Michele,David G. Strauss +18 more
TL;DR: In this preliminary study involving healthy volunteers, application of 4 commercially available sunscreens under maximal use conditions resulted in plasma concentrations that exceeded the threshold established by the FDA for potentially waiving some nonclinical toxicology studies forSunscreen ingredients.
Differentiating drug-induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil.
Lars Johannesen,Lars Johannesen,Jose Vicente,Jose Vicente,Jay W. Mason,Carlos Sanabria,K Waite-Labott,M Hong,P Guo,J Lin,J S Sørensen,Loriano Galeotti,Jeffry Florian,Martin Ugander,Martin Ugander,Norman Stockbridge,David G. Strauss,David G. Strauss +17 more
TL;DR: Characterization of multichannel drug effects on human cardiac repolarization is possible and may improve the utility of the electrocardiogram in the assessment of drug‐related cardiac electrophysiology.
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Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.
Murali K. Matta,Jeffry Florian,Robbert Zusterzeel,Nageswara Rao Pilli,Vikram Patel,Donna A. Volpe,Yang Yang,Luke Oh,Edward D. Bashaw,Issam Zineh,Carlos Sanabria,Sarah Kemp,Anthony Godfrey,Steven Adah,Sergio G. Coelho,Jian Wang,Lesley Anne Furlong,Charles J. Ganley,Theresa Michele,David G. Strauss +19 more
TL;DR: The systemic absorption and pharmacokinetics of the 6 active ingredients of sunscreen active ingredients in 4 sunscreen products under single- and maximal-use conditions were assessed to determine the systemic absorption of additional active ingredients and how quickly systemic exposure exceeds 0.5 ng/mL.
Earlier Sustained Virologic Response End Points for Regulatory Approval and Dose Selection of Hepatitis C Therapies
Jianmeng Chen,Jianmeng Chen,Jeffry Florian,Wendy Carter,Russell Fleischer,Thomas Hammerstrom,Pravin R. Jadhav,Wen Zeng,Jeffrey Murray,Debra Birnkrant +9 more
TL;DR: SVR12 and SVR24 measurements were concordant in a large population of subjects with HCV infection who participated in clinical trials with various treatment regimens and durations, suggesting SVR12 is suitable as a primary end point for regulatory approval.
173
Population Pharmacokinetic and Concentration—QTc Models for Moxifloxacin: Pooled Analysis of 20 Thorough QT Studies
TL;DR: To increase the understanding of important subject characteristics and design variables affecting the performance of oral moxifloxacin in thorough QT studies, population pharmacokinetic and concentration—QTc models were developed by pooling data from 20 studies.
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