Jeffrey Templin
University of Wisconsin–Milwaukee
3 Papers
94 Citations
Jeffrey Templin is an academic researcher from University of Wisconsin–Milwaukee. The author has contributed to research in topics: Bleomycin & Bleomycin A2. The author has an hindex of 3, co-authored 3 publications.
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Papers
•Journal Article
Intracellular DNA strand scission and growth inhibition of Ehrlich ascites tumor cells by bleomycins.
TL;DR: The generation of this class of damaged DNA correlates more closely with concentration-dependent growth inhibition by each of the six forms of bleomycin than the degree of random strand scission.
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Spin-trapping studies of the oxidation-reduction reactions of iron bleomycin in the presence of thiols and buffer.
William E. Antholine,Balaraman Kalyanaraman,Jeffrey Templin,Robert W. Brynes,David H. Peterings +4 more
TL;DR: In this paper, the reaction of Fe(II)bleomycin with dioxygen was reexamined to clarify whether radical species derived from molecular oxygen are generated. But the reaction was performed in the absence of spin trap.
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Properties of redox-inactivated bleomycins. In vitro DNA damage and inhibition of Ehrlich cell proliferation.
Jeffrey Templin,Lori Berry,Suzanne Lyman,Robert W. Byrnes,William E. Antholine,David H. Petering +5 more
TL;DR: Prior reaction of bleomycins with Fe2+ did not alter their capacity to reduce oxygen or affect their ability to generate the activated intermediate which, for native bleomycin structures, is competent to cleave DNA in vitro.
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