Jeffrey R. Idle
Long Island University
271 Papers
4.2K Citations
Jeffrey R. Idle is an academic researcher from Long Island University. The author has contributed to research in topics: Debrisoquine & Metabolite. The author has an hindex of 70, co-authored 261 publications. Previous affiliations of Jeffrey R. Idle include University of Newcastle & University of Birmingham.
Chat about Author
Papers
The relative importance of N-oxidation and N-demethylation in the metabolism of trimethylamine in man.
TL;DR: The metabolism of orally administered trimethylamine has been studied in 4 male volunteers at 2 dose levels and N-Oxidation was the major route of metabolism whilst N-demethylation was negligible and only significant at the higher dose level.
35
A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics
Fei Li,Andrew D. Patterson,Constance C. Höfer,Kristopher W. Krausz,Frank J. Gonzalez,Jeffrey R. Idle,Jeffrey R. Idle +6 more
TL;DR: Investigation of the metabolism of thioTEPA in a mouse model using ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry based-metabolomics provides useful information to understand comprehensively the pharmacological activity and potential toxicity of thiodiglycolic acid in the clinic.
34
•Journal Article
Interstrain comparison of hepatic and renal microsomal carcinogen metabolism and liver S9-mediated mutagenicity in DA and Lewis rats phenotyped as poor and extensive metabolizers of debrisoquine.
E Hietanen,Christian Malaveille,A.-M. Camus,J C Béréziat,G. Brun,M. Castegnaro,J. Michelon,Jeffrey R. Idle,Helmut Bartsch +8 more
TL;DR: The data suggest that ochratoxin A 4-Hydroxylase activity, which is low in the DA strain, is catalyzed by a cytochrome P-450 isozyme different from that responsible for debrisoquine 4-hydroxylation, which provides some insight into why the two metabolic oxidation phenotypes show different susceptibility to cancer induction and to the toxicity of certain environmental carcinogens.
33