Jeffrey R. Idle
Long Island University
271 Papers
4.2K Citations
Jeffrey R. Idle is an academic researcher from Long Island University. The author has contributed to research in topics: Debrisoquine & Metabolite. The author has an hindex of 70, co-authored 261 publications. Previous affiliations of Jeffrey R. Idle include University of Newcastle & University of Birmingham.
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Papers
Metabolic profiling of praziquantel enantiomers
Haina Wang,Zhong-Ze Fang,Yang Zheng,Kun Zhou,Changyan Hu,Kristopher W. Krausz,Dequn Sun,Jeffrey R. Idle,Frank J. Gonzalez +8 more
TL;DR: In silico, in vitro, and in vivo methods revealed the enantioselective metabolic profile of praziquantel, showing that chirality resulted in differences in substrate location and conformation, which likely accounts for the metabolic differences.
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•Journal Article
The gene CYP3 encoding P450pcn1 (nifedipine oxidase) is tightly linked to the gene COL1A2 encoding collagen type 1 alpha on 7q21-q22.1.
B A Brooks,O W McBride,Colin T. Dolphin,Martin Farrall,P.J. Scambler,Frank J. Gonzalez,Jeffrey R. Idle +6 more
TL;DR: Tight linkage emerged between CYP3 and COL1A2, with a maximum combined lod score of 5.72 at theta = 0, suggesting the most likely subchromosomal localization of CYP 3 is 7q21.3-q22.1.
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•Journal Article
Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons.
TL;DR: It is indicated that hitherto apparently inert ifosfamide metabolites, in particular SCMC, activate AMPA/kainate receptors and induce cellular acidification, both of which could provide the biochemical basis of the observed ifOSfamide-associated encephalopathy.
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Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge
Joo Youn Cho,Tsutomu Matsubara,Dong Wook Kang,Sung-Hoon Ahn,Kristopher W. Krausz,Jeffrey R. Idle,Hans Luecke,Frank J. Gonzalez +7 more
TL;DR: In this article, the results of metabolomic responses were investigated in urine of wild-type and Fxr-null mice fed cholic acid, an FXR ligand, using ultra-performance liquid chromatography (UPLC) coupled with electrospray time-of-flight mass spectrometry (TOFMS).
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Pharmacokinetics, metabolism and clinical effect of ifosfamide in breast cancer patients
TL;DR: Results give some insight into a possible mechanism of action of ifosfamide and indicate that some species other than IPM, as measured systemically, is responsible for the pharmacological effects of this drug.
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