Jeffrey R. Idle
Long Island University
271 Papers
4.2K Citations
Jeffrey R. Idle is an academic researcher from Long Island University. The author has contributed to research in topics: Debrisoquine & Metabolite. The author has an hindex of 70, co-authored 261 publications. Previous affiliations of Jeffrey R. Idle include University of Newcastle & University of Birmingham.
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Papers
Nomenclature for human CYP2D6 alleles.
Ann K. Daly,Jürgen Brockmöller,Franck Broly,Michel Eichelbaum,William E. Evans,Frank J. Gonzalez,J D Huang,Jeffrey R. Idle,Magnus Ingelman-Sundberg,Takashi Ishizaki,Evelyne Jacqz-Aigrain,Urs A. Meyer,Daniel W. Nebert,Vidar M. Steen,C R Wolf,Ulrich M. Zanger +15 more
TL;DR: It is proposed that alleles be designated by CYP2D6 followed by an asterisk and a combination of roman letters and arabic numerals distinct for each allele with the number specifying the key mutation and, where appropriate, a letter specifying additional mutations.
421
Metabolic oxidation phenotypes as markers for susceptibility to lung cancer
TL;DR: It is concluded that the gene controlling debrisoquine 4-hydroxylation may be a host genetic determinant of susceptibility to lung cancer in smokers and that it represents a marker to assist in assessing individual risk.
388
Metabolism of melatonin by human cytochromes p450.
TL;DR: Comparison of brain homogenates from wild-type and cyp1b1-null mice revealed that MEL 6-hydroxylation was clearly mediated to a significant degree by CYP1B1, the first time that CYP 1B1 has been shown to 6-Hydroxylate MEL.
319
LC-MS-based metabolomics in drug metabolism.
TL;DR: In this review, the technological elements of LC- MS-based metabolomics for constructing high-quality datasets and conducting comprehensive data analysis are examined and four novel approaches of using LC-MS- based metabolomic techniques in xenobiotic metabolism research are proposed.
The role of individual human cytochromes P450 in drug metabolism and clinical response.
TL;DR: The molecular basis of this deficiency is now well understood and methods for the detection of poor metabolizers are discussed, as well as the effect of the polymorphism on drug metabolism.
259