Jeffrey L. Cummings
University of Nevada, Las Vegas
933 Papers
6.5K Citations
Jeffrey L. Cummings is an academic researcher from University of Nevada, Las Vegas. The author has contributed to research in topics: Dementia & Medicine. The author has an hindex of 148, co-authored 833 publications. Previous affiliations of Jeffrey L. Cummings include Cleveland Clinic Lerner College of Medicine & University of California, Los Angeles.
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Papers
Optimizing measurement of agitation and aggression in dementia
Suzanne Hendrix,Bruce L. Brown,Jeffrey L. Cummings,Constantine G. Lyketsos,Anton P. Porsteinsson,Paul B. Rosenberg,Mary Sano +6 more
TL;DR: In this study of 684 subjects with mild to moderate AD, 35 mg intepirdine in conjunction withdonepezil resulted in 47.7% less decline over 48 weeks compared to donepezil alone.
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The Role of Clinical Trials in Preclinical Alzheimer's Disease Drug Development Programs.
Jeffrey L. Cummings
- 01 Jan 2020
TL;DR: Recognition of this long-preclinical phase and the presence of biomarker changes affords, the opportunity to plan secondary prevention trials to prevent or delay the onset of cognitive impairment and progression to dementia.
HARMONY Study: Pimavanserin Significantly Prolongs Time to Relapse of Dementia-Related Psychosis
Pierre N. Tariot,Erin P. Foff,Jeffrey L. Cummings,Maria-Eugenia Soto-Martin,Bradley McEvoy,Srdjan Stankovic,Amy Howard +6 more
TL;DR: The Harmony study demonstrated a robust decrease in hallucinations and delusions and significant maintenance of efficacy with pimavanserin treatment in DRP and stopped early for superior efficacy when a prespecified interim analysis revealed >2.8-fold reduction in risk of relapse.
Neuropsychiatric symptom profiles in Mild Cognitive Impairment and Alzheimer's disease
TL;DR: The findings underlies appropriateness to deal with FTLD subgroups in clinical setting differently as this clinical syndrome may reflect various underlying pathophysiological processes and usefulness of non-amnestic MCI concept should be challenged in these circumstances.
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