Jeffrey D. Peterson
PerkinElmer
27 Papers
179 Citations
Jeffrey D. Peterson is an academic researcher from PerkinElmer. The author has contributed to research in topics: In vivo & Ex vivo. The author has an hindex of 13, co-authored 27 publications.
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Papers
Quantitative whole body biodistribution of fluorescent-labeled agents by non-invasive tomographic imaging.
TL;DR: The studies demonstrate the ability of quantitative FMT imaging of FR/NIR agents to non-invasively visualize and quantify the biodistribution of different agents over time.
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Dual In Vivo Quantification of Integrin-targeted and Protease-activated Agents in Cancer Using Fluorescence Molecular Tomography (FMT)
Sylvie Kossodo,Maureen Pickarski,Shu-An Lin,Alexa Gleason,Renee C. Gaspar,Chiara Buono,Guojie Ho,Agnieszka Blusztajn,Garry Cuneo,Jun Zhang,Jayme Jensen,Richard Hargreaves,Paul J. Coleman,George D. Hartman,Milind Rajopadhye,Le Thi Duong,Cyrille Sur,Wael Yared,Jeffrey D. Peterson,Bohumil Bednar +19 more
TL;DR: NIRF-labeled integrin antagonists allow noninvasive molecular fluorescent imaging and quantification of tumors in vivo, improving and providing more refined approaches for cancer detection and treatment monitoring.
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In Vivo Imaging and Quantification of Carbonic Anhydrase IX Expression as an Endogenous Biomarker of Tumor Hypoxia
Bagna Bao,Kevin Groves,Jun Zhang,Emma Handy,Paul Kennedy,Garry Cuneo,Claudiu T. Supuran,Wael Yared,Milind Rajopadhye,Jeffrey D. Peterson +9 more
TL;DR: A spatial correlation of fluorescence signal obtained by non-invasive, tomographic imaging of HS680 with regions of hypoxia and CA IX expression is established, crucial to the study of the underlying biology of hypoxic tumors and the development and monitoring of novel anti-cancer therapies.
Noninvasive In Vivo Quantification of Neutrophil Elastase Activity in Acute Experimental Mouse Lung Injury
Sylvie Kossodo,Jun Zhang,Kevin Groves,Garry Cuneo,Emma Handy,Jeff Morin,Jeannine Delaney,Wael Yared,Milind Rajopadhye,Jeffrey D. Peterson +9 more
TL;DR: A neutrophil elastase-specific near-infrared fluorescence imaging agent was developed, which was significantly activated ex vivo in lung sections from ALI but not from control mice, and this activation was ablated by the specific inhibitor sivelestat.
A macrophage uptaking near-infrared chemical probe CDnir7 for in vivo imaging of inflammation
Nam-Young Kang,Sungjin Park,Xiao Wei Emmiline Ang,Animesh Samanta,Wouter H. P. Driessen,Vasilis Ntziachristos,Kristine O. Vasquez,Jeffrey D. Peterson,Seong-Wook Yun,Young-Tae Chang,Young-Tae Chang +10 more
TL;DR: A near infrared (NIR) probe is developed that can selectively detect macrophages and visualize inflammation in vivo using the IVIS spectrum, Fluorescence Molecular Tomography and Multi-Spectral Optoacoustic Tomography.
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