Jeffery W. Kelly
Scripps Research Institute
447 Papers
4.7K Citations
Jeffery W. Kelly is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Transthyretin & Chemistry. The author has an hindex of 108, co-authored 428 publications. Previous affiliations of Jeffery W. Kelly include University of North Carolina at Chapel Hill & Texas A&M University.
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Papers
Amplifiers co-translationally enhance CFTR biosynthesis via PCBP1-mediated regulation of CFTR mRNA
Danijela Dukovski,Adriana Villella,Cecilia M. Bastos,Randall W. King,Daniel Finley,Jeffery W. Kelly,Richard I. Morimoto,F. Ulrich Hartl,Benito Munoz,Po Shun Lee,Marija Zecevic,J.P. Miller +11 more
TL;DR: The mechanism by which amplifiers increase CFTR mRNA, protein, and activity is characterized, representing a promising new and mechanistically novel class of CFTR therapeutic that may be useful as a monotherapy or in combination with other CFTR modulators.
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Intermolecular Disulfide Linkages Are Not Required for Transthyretin Amyloid Fibril Formation in Vitro
TL;DR: Results are inconsistent with a recently proposed model stressing the importance of intermolecular disulfide linkages in TTR amyloid fibril formation, but are consistent with a model relying on noncovalent quaternary contacts made possible through an acid-mediated conformational change.
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Controlling the Morphology of Cross β-Sheet Assemblies by Rational Design
TL;DR: Low molecular weight peptidomimetics with simple amphiphilic sequences can help to elucidate the structures of cross β-sheet assemblies, such as amyloid fibrils, with high precision.
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ATF6 is essential for human cone photoreceptor development
Heike Kroeger,Julia M. D. Grandjean,Wei-Chieh Jerry Chiang,Daphne D. Bindels,Rebecca Mastey,Jennifer Okalova,Amanda Nguyen,Evan T. Powers,Jeffery W. Kelly,Neil Grimsey,Michel Michaelides,Michel Michaelides,Joseph Carroll,R. Luke Wiseman,Jonathan H. Lin,Jonathan H. Lin +15 more
TL;DR: In this paper, the authors show that selective small molecule ATF6 signaling agonist restores the transcriptional activity of some ATF6 disease-causing variants and stimulates cone growth and gene expression in patient retinal organoids carrying these variants.
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Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis.
TL;DR: A family of fluorogenic stilbene-based vinyl amides and vinyl sulfonamides that covalently modify transthyretin (TTR) tracelessly are described, good enough in human plasma to serve as a starting point for medicinal chemistry efforts.