Jeff W. Lichtman
Harvard University
317 Papers
4.8K Citations
Jeff W. Lichtman is an academic researcher from Harvard University. The author has contributed to research in topics: Postsynaptic potential & Neuromuscular junction. The author has an hindex of 86, co-authored 282 publications. Previous affiliations of Jeff W. Lichtman include University of California, San Diego & Washington University in St. Louis.
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Papers
Elimination of synapses in the developing nervous system.
Dale Purves,Jeff W. Lichtman +1 more
TL;DR: Reduction of the number of axons that contact target cells may be a general feature of neural development and underlie the progressively restricted malleability of the maturing nervous system.
Sustained Delivery of VEGF Maintains Innervation and Promotes Reperfusion in Ischemic Skeletal Muscles Via NGF/GDNF Signaling
Dmitry Shvartsman,Dmitry Shvartsman,Hannah Storrie-White,Kangwon Lee,Kangwon Lee,Cathal J. Kearney,Yevgeny Brudno,Yevgeny Brudno,Nhi Ho,Christine A. Cezar,Corey M. McCann,Erin M. Anderson,Erin M. Anderson,John Koullias,Juan Carlos Tapia,Herman H. Vandenburgh,Jeff W. Lichtman,David J. Mooney,David J. Mooney +18 more
TL;DR: It is shown that the delivery of vascular endothelial growth factor from alginate hydrogels ameliorates loss of skeletal muscle innervation after ischemic injury by promoting both maintenance and regrowth of damaged axons in mice.
Post-embryonic remodeling of the C. elegans motor circuit
Benjamin Mulcahy,Daniel Witvliet,James E. Mitchell,Richard Schalek,Daniel R. Berger,Yuelong Wu,Doug Holmyard,Yangning Lu,Tosif Ahamed,Aravinthan D. T. Samuel,Andrew D. Chisholm,Jeff W. Lichtman,Mei Zhen +12 more
TL;DR: In this paper , the authors reconstructed the C. elegans motor circuit by electron microscopy across larval development and observed the following: embryonic motor neurons transiently interact with the developing post-embryonic motor neurons prior to remodeling of their juvenile wiring.
Controlling the Orientation and Synaptic Differentiation of Myotubes with Micropatterned Substrates
Jacinthe Gingras,Robert M. Rioux,Damien Cuvelier,Nicholas A. Geisse,Jeff W. Lichtman,George M. Whitesides,Lakshminarayanan Mahadevan,Joshua R. Sanes +7 more
TL;DR: A simple geometrical model predicts the angle and extent of orientation based on maximizing the contact area between the myoblasts and patterned topographic surfaces and sheds light on mechanisms of myotube alignment in vivo.
High-throughput ultrastructural analysis of macular telangiectasia type 2
Charles L. Zucker,Paul S. Bernstein,Richard Schalek,Jeff W. Lichtman,John E. Dowling +4 more
TL;DR: High-throughput electron microscopy reveals mitochondrial structural changes in macular telangiectasia type 2, a rare macular degeneration, affecting retinal cell types outside the retinal pigment epithelium, with potential implications for serine deficiency and mitochondrial dysfunction.