Jeff W. Lichtman
Harvard University
317 Papers
4.8K Citations
Jeff W. Lichtman is an academic researcher from Harvard University. The author has contributed to research in topics: Postsynaptic potential & Neuromuscular junction. The author has an hindex of 86, co-authored 282 publications. Previous affiliations of Jeff W. Lichtman include University of California, San Diego & Washington University in St. Louis.
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Papers
Reversing the Outcome of Synapse Elimination at Developing Neuromuscular Junctions In Vivo: Evidence for Synaptic Competition and Its Mechanism
TL;DR: Competition between neurons for the same synaptic sites at the developing neuromuscular junction drives synaptic rearrangements.
The interscutularis muscle connectome.
TL;DR: The reconstructed connectomes of six interscutularis muscles from adult transgenic mice expressing fluorescent proteins in all motor axons revealed several organizational principles of the neuromuscular circuit, and showed that mammalian muscle function is implemented with a variety of wiring diagrams that share certain global features but differ substantially in anatomical form.
Axon branch removal at developing synapses by axosome shedding.
Derron L. Bishop,Thomas Misgeld,Thomas Misgeld,Mark K. Walsh,Wen-Biao Gan,Jeff W. Lichtman,Jeff W. Lichtman +6 more
TL;DR: Time-lapse imaging of fluorescently labeled axons and serial electron microscopy are combined to show that axons at neuromuscular junctions are removed by an unusual cellular mechanism, and as axons disappear, they shed numerous membrane bound remnants.
Lysosomal Activity Associated with Developmental Axon Pruning
Jae W. Song,Thomas Misgeld,Hyuno Kang,Sharm Knecht,Ju Lu,Yi Cao,Susan L. Cotman,Derron L. Bishop,Jeff W. Lichtman +8 more
TL;DR: It is proposed that lysosomal activity is a central feature of synapse elimination and may serve as a marker for regions of the developing nervous system undergoing axon pruning.
Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex
Xiaomeng Han,Peter H. Li,Shuohong Wang,Richard Schalek,Yaron Meirovitch,Zudi Lin,Jason Adhinarta,Karl D. Murray,Leah M. MacNiven,Daniel R. Berger,Yuelong Wu,Tao Fang,Elif Sevde Meral,Shadnan Asraf,Hidde Ploegh,Hanspeter Pfister,Donglai Wei,Viren Jain,James S. Trimmer,Jeff W. Lichtman +19 more
TL;DR: Researchers developed a multiplexed volumetric CLEM approach using scFvs to combine ultrastructure and molecular information in the cerebellar cortex, revealing new cell types and ion channel localization, and enabling molecular overlays for connectomic studies.