Jeff M. Reece
National Institutes of Health
7 Papers
34 Citations
Jeff M. Reece is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Inositol & Actin cytoskeleton. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of Jeff M. Reece include Durham University & Research Triangle Park.
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Papers
Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo.
Shilpa Thakur,Brianna Daley,Kelli Gaskins,Vasyl Vasko,Myriem Boufraqech,Dhaval Patel,Carole Sourbier,Jeff M. Reece,Sheue-yann Cheng,Electron Kebebew,Sunita K. Agarwal,Joanna Klubo-Gwiezdzinska +11 more
TL;DR: It is demonstrated for the first time that MGPDH is overexpressed in thyroid cancer compared with normal thyroid, and it is established thatMGPDH regulates human thyroid cancer cell growth and OXPHOS rate in vitro.
Luminescence-activated nucleotide cyclase regulates spatial and temporal cAMP synthesis.
Nyla Naim,Alex D. White,Jeff M. Reece,Mamta Wankhede,Xuefeng Zhang,Jean-Pierre Vilardaga,Daniel L. Altschuler +6 more
TL;DR: It is shown that cAMP produced in the cytosol and nucleus stimulates proliferation in thyroid cells, and the bPAC–nLuc fusion construct adds a new reagent to the available toolkit to study cAMP-regulated processes in living cells.
15
Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis
TL;DR: This adaptation, which improves purinergic activation of Ca2+-dependent Cl- secretion in CF MTEs, was exceptionally specific; there was no effect upon the cellular levels of all the other inositol phosphate signals.
Pathogenicity of Salmonella: SopE-mediated membrane ruffling is independent of inositol phosphate signals.
TL;DR: It is demonstrated that Salmonella‐mediated cytoskeletal modifications are independent of inositolphosphates, and will focus future studies on elucidating alternate pathogenic consequences of InsP5 metabolism, including ion channel conductance and apoptosis.
7
Nutrient sensing pathways regulating adult reproductive diapause in C. elegans
Moriah Eustice,Jeff M. Reece,Daniel Konzman,Salil Ghosh,Jhulian Alston,Tyler J. Hansen,Andy Golden,John A. Hanover +7 more
TL;DR: A candidate-based genetic screen analyzing select nutrient-sensing pathways identifies novel conserved genetic pathways required for ARD entry and recovery and identifies new genetic interactions that provide insight into the role of OGT and OGA.