Jeff E. Cobb
Research Triangle Park
11 Papers
204 Citations
Jeff E. Cobb is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Receptor & Lactam. The author has an hindex of 6, co-authored 11 publications.
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Papers
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.
Lisa M. Leesnitzer,Derek J. Parks,Randy K. Bledsoe,Jeff E. Cobb,Jon L. Collins,Thomas G. Consler,Roderick G. Davis,Emily A. Hull-Ryde,James M. Lenhard,Lisa G. Patel,Kelli D. Plunket,Jennifer L. Shenk,Julie B. Stimmel,Christina Therapontos,Timothy M. Willson,Steven G. Blanchard +15 more
TL;DR: The selective and irreversible nature of GW9662 treatment, and the observation that activity is maintained in cell culture experiments, suggests that this compound may be a useful tool for elucidation of the role of PPARgamma in biological processes.
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N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 3. Structure−Activity Relationship and Optimization of the N-Aryl Substituent
Jeff E. Cobb,Steven G. Blanchard,Evan G. Boswell,Kathleen K. Brown,Paul S. Charifson,Joel P. Cooper,Jon L. Collins,Milana Dezube,Brad R. Henke,Emily A. Hull-Ryde,Debra H. Lake,James M. Lenhard,William R. Oliver,Jeffery Oplinger,Mila Pentti,Derek J. Parks,Kelli D. Plunket,Wei-Qin Tong +17 more
TL;DR: A series of novel carboxylic acid analogues, 23-66, modified only in the N-2-benzoylphenyl moiety were synthesized from L-tyrosine and evaluated as PPARgamma agonists and found to normalize glycemia when dosed at 3 mg/kg bid po in the Zucker diabetic fatty rat model of type 2 diabetes.
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Expression Cloning and Receptor Pharmacology of Human Calcitonin Receptors from MCF-7 Cells and Their Relationship to Amylin Receptors
Wen Ji Chen,Susan Armour,James M. Way,Grace Chen,Chris Watson,Paul E. Irving,Jeff E. Cobb,Sue H. Kadwell,Kevin Beaumont,Thomas J. Rimele,Terry P. Kenakin +10 more
TL;DR: Human breast cell carcinoma MCF-7 cells were found to bind 125I-labeled rat amylin (rAmylin) and the peptide isylin antagonist radioligand125I-AC512 with high affinity, and the agonists hCAL and rAmylin were much more potent in displacing their radiolIGand counterparts than was the antagonist radiolaigand 125I -AC512.
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Inhibition of pyruvate dehydrogenase kinase by halogenated acetophenones
TL;DR: A series of halogenated acetophenones with potent activity against PDH‐Kinase (IC50 1–3 μM) and inactive towards other protein kinases was identified and the lead compound displayed non‐linear kinetics and was shown to be an uncompetitive inhibitor with respect to ATP.
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