Jee-Young Lee

TL;DR: In this article, a fumagillol compound was used as an angiogenesis inhibiting agent showing a superior angeogenesis inhibitory effect with less toxicity, but also as a cancer metastasis inhibitor and a therapeutic agent against cancer and other various inflammatory diseases such as rheumatic disease, psoriasis, etc.

TL;DR: It is suggested that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.

TL;DR: To identify novel compounds to inhibit binding interface between Rab27a and melanophilin, a pharmacophore model was built based on a modeled 3D structure of the protein complex that describes the essential binding residues in the intermolecular interaction and two hydroxyl functional groups were found to be critical for blocking the interMolecular binding.

TL;DR: Analysis of ligand-protein binding model implies that Arg201 on hCOMT plays important roles in the interactions with COMT inhibitors, which may give insight to develop new ways of antiparkinson drug.