Jean-Pierre Pelletier
Université de Montréal
375 Papers
2.4K Citations
Jean-Pierre Pelletier is an academic researcher from Université de Montréal. The author has contributed to research in topics: Osteoarthritis & Medicine. The author has an hindex of 79, co-authored 347 publications.
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Papers
Intracellular localisation of galectin-3 has a protective role in chondrocyte survival
Christelle Boileau,Françoise Poirier,Jean-Pierre Pelletier,Mélanie Guévremont,Nicolas Duval,Johanne Martel-Pelletier,Pascal Reboul +6 more
TL;DR: In vitro experiments demonstrated that intracellular gal-3 had a protective role in chondrocyte survival, which involved its phosphorylation, as its absence in KO mice led to cartilage lesions.
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Identification of the most important features of knee osteoarthritis structural progressors using machine learning methods.
Afshin Jamshidi,Mickael Leclercq,Aurélie Labbe,Jean-Pierre Pelletier,François Abram,Arnaud Droit,Johanne Martel-Pelletier +6 more
TL;DR: Data revealed baseline X-ray and MRI-based features could predict early OA knee progressors and that MLP is the best classification method for knee OA structural progressors.
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Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism.
Tanja Kalajdzic,Wissam H. Faour,Qing Wen He,Hassan Fahmi,Johanne Martel-Pelletier,Jean-Pierre Pelletier,John A. Di Battista +6 more
TL;DR: PPAR-mediated induction of COX-2 expression and synthesis in human OA synovial fibroblasts is inhibited by therapeutic concentrations of NIM through the functional antagonism of ligand-dependent receptor activation, with the resultant suppression of PPAR-dependent transactivation of target genes.
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•Journal Article
Diacerein reduces the level of cartilage chondrocyte DNA fragmentation and death in experimental dog osteoarthritic cartilage at the same time that it inhibits caspase-3 and inducible nitric oxide synthase.
TL;DR: This study shows that diacerein/rhein can effectively reduce the level of OA chondrocyte DNA fragmentation and death under the present experimental conditions.
Modulation of collagenase 3 in human osteoarthritic cartilage by activation of extracellular transforming growth factor β: Role of furin convertase
Florina Moldovan,Jean-Pierre Pelletier,François Mineau,Martine Dupuis,Jean-Marie Cloutier,Johanne Martel-Pelletier +5 more
TL;DR: The mechanisms of TGFbeta activation/ activity with regard to collagenase 3 modulation in cartilage appear to be controlled by furin convertase with or without M6P/IGF-2R.
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