Jean-Louis Laplanche
University of Paris
195 Papers
1.9K Citations
Jean-Louis Laplanche is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & PRNP. The author has an hindex of 48, co-authored 183 publications. Previous affiliations of Jean-Louis Laplanche include Paris Diderot University & French Institute of Health and Medical Research.
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Papers
Substitutions at residue 211 in the prion protein drive a switch between CJD and GSS syndrome, a new mechanism governing inherited neurodegenerative disorders
Katell Peoc'h,Etienne Levavasseur,Emilien Delmont,Alfonso De Simone,Isabelle Laffont-Proust,Nicolas Privat,Yassmine Chebaro,Céline Chapuis,Pierre Bedoucha,Jean-Philippe Brandel,Annie Laquerrière,Jean-Louis Kemeny,Jean-Jacques Hauw,M. Borg,Human Rezaei,Philippe Derreumaux,Jean-Louis Laplanche,Stéphane Haïk +17 more
TL;DR: Significant differences in the PrP primary structure and stability are sufficient to control amyloid plaques formation and tau abnormal phosphorylation and fibrillation, which is consistent with the prion hypothesis that proposes a conformational change as the key pathological event in prion disorders.
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Long-standing prion dementia manifesting as posterior cortical atrophy.
Raphaël Depaz,Stéphane Haïk,Katell Peoc'h,Danielle Seilhean,David Grabli,Savine Vicart,Marie Sarazin,Bertrand DeToffol,Catherine Remy,Catherine Fallet-Bianco,Jean-Louis Laplanche,Bertrand Fontaine,Jean Philippe Brandel +12 more
TL;DR: The clinical and neuropathological features of a family with an early and long-standing dementia manifesting with posterior cortical atrophy and related to a 120 bp insertional mutation of the prion protein gene are presented.
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Determination of 14-3-3 protein levels in cerebrospinal fluid from Creutzfeldt-Jakob patients by a highly sensitive capture assay.
TL;DR: The levels of the gamma-isoform of 14-3-3 protein in CSF samples from CJD patients were significantly higher than those observed in patients with non-CJD dementias suggesting that this capture assay is a reliable method in the diagnosis of CJD.
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Creutzfeldt‐Jakob disease after extracranial dura mater embolization for a nasopharyngeal angiofibroma
J. C. Antoine,D. Michel,P Bertholon,J. F. Mosnier,Jean-Louis Laplanche,P. Beaudry,J. J. Hauw,C. Veyret +7 more
TL;DR: A 25-year-old man with Creutzfeldt-Jakob disease who had received dura mater embolization in the external carotid artery for a nasopharyngeal angiofibroma 90 months earlier is reported, suggesting that dura Matter Embolization can be responsible for the CJD.
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•Journal Article
Differential expression of the prion-like protein doppel gene (PRND) in astrocytomas: a new molecular marker potentially involved in tumor progression
Sergio Comincini,Angelica Facoetti,Igor Del Vecchio,Katell Peoc'h,Jean-Louis Laplanche,Lorenzo Magrassi,Mauro Ceroni,Luca Ferretti,Rosanna Nano +8 more
TL;DR: The findings suggest that the PRND gene might be a useful molecular marker in astrocytoma progression and in tumor grade definition and understanding of the mechanisms of PRND increased expression might provide insight into the regulatory pathways of glioma development.
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